Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. It is released in response to stress, and to a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis, suppress the immune system, and aid in fat, protein, and carbohydrate metabolism. It also decreases bone formation. Various synthetic forms of cortisol are used to treat a variety of different illnesses.
Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):24.
Expression of ATP-Binding Cassette Transporter A1 (ABCA1) in Eyelid Tissues and Meibomian Gland Epithelial Cells
Hydrocortisone purchased from AbMole
BMC Ophthalmol. 2021 Feb 25;21(1):104.
Heme relieves the inhibition of proliferation, migration and angiogenesis of HMEC-1 under hyperoxia by inhibiting BACH1
Hydrocortisone purchased from AbMole
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Source | BMC Ophthalmology. 2020 Nov. Figure 1. hydrocortisone (Abmole Bioscience, USA) |
| Method | proliferation ability assay | |
| Cell Lines | HMEC-1 cell | |
| Concentrations | 1μg/ml | |
| Incubation Time | - | |
| Results | Under hyperoxia condition, the proliferation of HMEC-1 is inhibited, 5-40 µM heme promoted the proliferation ability of HMEC-1, more than or equal to 80 µM showed inhibition |
| Molecular Weight | 362.46 |
| Formula | C21H30O5 |
| CAS Number | 50-23-7 |
| Solubility (25°C) | DMSO 33 mg/mL Ethanol 10 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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