About 8 results found for searched term "GCR" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3465 | Triamcinolone | Others |
| Triamcinolone is a long-acting corticosteroid. Triamcinolone is a corticosteroid hormone receptor (GCR) agonist and an anti-inflammatory agent. | ||
| M3527 | Clinofibrate | HMG-CoA Reductase |
| S-8527 | ||
| Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood. | ||
| M20528 | Pravastatin | HMG-CoA Reductase |
| Pravastatin is an HMG-CoA reductase (HMGCR) inhibitor that inhibits sterol synthesis with an IC50 of 5.6 μM. | ||
| M27634 | Simvastatin hydroxy acid sodium | HMG-CoA Reductase |
| Tenivastatin sodium; Simvastatin Impurity A sodium | ||
| Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | ||
| M27949 | Simvastatin acid | HMG-CoA Reductase |
| Tenivastatin | ||
| Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin, is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | ||
| M28329 | Simvastatin acid ammonium | HMG-CoA Reductase |
| Tenivastatin ammonium | ||
| Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | ||
| M28512 | Rosuvastatin Sodium | HMG-CoA Reductase |
| ZD 4522 Sodium; X-Plended Sodium; Crestor Sodium | ||
| Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels. | ||
| M42442 | Bemfivastatin | HMG-CoA Reductase |
| Bemfivastatin (PPD 10558) is an orally active, HMG-CoA Reductase (HMGCR) inhibitor, also known as Statin. | ||
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