Triton X-100

Biological Activity

Triton X-100 is a nonionic, non-denaturing detergent suitable for solubilization, isolation and purification of membrane protein complexes. It is chemically indistinguishable from Nonidet P-40.

Product Citations

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  Theranostics. 2022 Jul 7;12(12):5317-5329.

  Recapitulating influenza virus infection and facilitating antiviral and neuroprotective screening in tractable brain organoids
  Triton X-100 purchased from AbMole

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  Molecules . 2022 May 6;27(9):2994.

  Inosine and D-Mannose Secreted by Drug-Resistant Klebsiella pneumoniae Affect Viability of Lung Epithelial Cells
  Triton X-100 purchased from AbMole

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  Front Pharmacol . 2022 Jul 18;13:943111.

  (±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H 2 O 2 Through Activation of Nrf2 Pathway
  Triton X-100 purchased from AbMole

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  Nucleic Acids Res. 2022 Aug 12;50(14):7938-7958.

  HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia
  Triton X-100 purchased from AbMole

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  Oxid Med Cell Longev . 2022 Jul 18;2022:5961123.

  Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE
  Triton X-100 purchased from AbMole

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  Cell Death Dis. 2022 Apr 5;13(4):303.

  KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response
  Triton X-100 purchased from AbMole

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  Front Pharmacol. 2021 Feb 16;12:625074.

  Saikosaponin D Rescues Deficits in Sexual Behavior and Ameliorates Neurological Dysfunction in Mice Exposed to Chronic Mild Stress
  Triton X-100 purchased from AbMole

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  Nanoscale. 2021 May 13;13(18):8614-8622.

  Ordered inverse-opal scaffold based on bionic transpiration to create a biomimetic spine
  Triton X-100 purchased from AbMole

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  Neural Plast. 2021 Apr 19;2021:6680192.

  The Wnt/ β-Catenin Pathway Regulated Cytokines for Pathological Neuropathic Pain in Chronic Compression of Dorsal Root Ganglion Model
  Triton X-100 purchased from AbMole

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  Int J Chron Obstruct Pulmon Dis. 2021 Jun 4;16:1661-1675.

  Histone Deacetylase 2 Suppresses Skeletal Muscle Atrophy and Senescence via NF-κB Signaling Pathway in Cigarette Smoke-Induced Mice with Emphysema
  Triton X-100 purchased from AbMole

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  Front Pharmacol. 2021 May 17;12:589273.

  Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
  Triton X-100 purchased from AbMole

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  DNA Cell Biol. 2021 Jul;40(7):895-905.

  AEG-1 Knockdown Sensitizes Glioma Cells to Radiation Through Impairing Homologous Recombination Via Targeting RFC5
  Triton X-100 purchased from AbMole

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  Nat Commun. 2020 Sep 15;11(1):4629.

  Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity
  Triton X-100 purchased from AbMole

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  Front Immunol. 2020 Oct 14;11:571959.

  Threonyl-tRNA Synthetase Promotes T Helper Type 1 Cell Responses by Inducing Dendritic Cell Maturation and IL-12 Production via an NF-κB Pathway
  Triton X-100 purchased from AbMole

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  Exp Cell Res. 2020 Nov 1;396(1):112237.

  LRTM1 promotes the differentiation of myoblast cells by negatively regulating the FGFR1 signaling pathway
  Triton X-100 purchased from AbMole

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  2020 Sep.

  Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
  Triton X-100 purchased from AbMole

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  Nat Biomed Eng. 2020 Sep;4(9):875-888.

  Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies
  Triton X-100 purchased from AbMole

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  Front Oncol. 2020 May 21;10:667.

  Downregulation of TET1 Promotes Bladder Cancer Cell Proliferation and Invasion by Reducing DNA Hydroxymethylation of AJAP1
  Triton X-100 purchased from AbMole

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  Drug Chem Toxicol. 2016 Oct;39(4):392-9.

  Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage
  Triton X-100 purchased from AbMole

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  Neurochem Res. 2020 Sep;45(9):2020-2031.

  MCC950 Inhibits NLRP3 Inflammasome and Alleviates Axonal Injures in Early Stages of Diffuse Axonal Injury in Rats
  Triton X-100 purchased from AbMole

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  Environ Health Perspect. 2020 Jun;128(6):67008.

  Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation
  Triton X-100 purchased from AbMole

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  Life Sci. 2020 Sep 15;257:118021.

  TRIB3 destabilizes tumor suppressor PPARα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia
  Triton X-100 purchased from AbMole

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  Anat Rec (Hoboken). 2020 Jan 21.

  Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
  Triton X-100 purchased from AbMole

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  Sci Adv. 2020 Jul 10;6(28):eaba7260.

  A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
  Triton X-100 purchased from AbMole

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  Aging (Albany NY). 2020 Jun 9;12(11):11025-11041.

  LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis
  Triton X-100 purchased from AbMole

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  PLoS Pathog. 2020 Apr 13;16(4):e1008498.

  Intestinal Restriction of Salmonella Typhimurium Requires caspase-1 and caspase-11 Epithelial Intrinsic Inflammasomes
  Triton X-100 purchased from AbMole

Chemical Information

Formula	C14H22O.n(C2H4O)
CAS Number	9002-93-1
Solubility (25°C)	Soluble in water
Storage	room temperature

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Harendra S, et al. J Environ Sci. Sorption and transport studies of cetyl trimethylammonium bromide (CTAB) and Triton X-100 in clayey soil.

[2] Zhao B, et al. Water Sci Technol. Micellar-enhanced ultrafiltration of copper ions using sodium dodecyl sulfate and its mixture with Brij 35, Tween 80 and Triton X-100.