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Streptomycin sulfate

Cat. No. M4947
Streptomycin sulfate Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 35  USD35 In stock
1g USD 40  USD40 In stock
10g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Streptomycin Sulfate is the sulfate salt form of streptomycin, an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial property. Streptomycin sulfate binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death. Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor.

Product Citations
Customer Product Validations & Biological Datas
Source Pharmaceuticals 2020 Mar. Figure 1. Streptomycin (Abmole Bioscience, USA)
Method Vitro Antiproliferative Assays
Cell Lines HepG2
Concentrations -
Incubation Time 48 h
Results At a fixed concentration of 100 g/mL, EL-MeOH and fractions from E. lanceolatus displayed antiproliferative activity depending on studied cells.
Chemical Information
Molecular Weight 581.57
Formula C21H39N7O12
CAS Number 3810-74-0
Solubility (25°C) Water 86 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sharma D,et.al. J Mol Biol Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome.

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