Streptomycin sulfate

Biological Activity

Streptomycin Sulfate is the sulfate salt form of streptomycin, an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial property. Streptomycin sulfate binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death. Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor.

Product Citations

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  Lipids Health Dis. 2021 Apr 26;20(1):40.

  Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease
  Streptomycin sulfate purchased from AbMole

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  J Inflamm Res. 2021 Mar 17;14:917-928.

  Stable Cells with NF-κB-ZsGreen Fused Genes Created by TALEN Editing and Homology Directed Repair for Screening Anti-inflammation Drugs
  Streptomycin sulfate purchased from AbMole

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  Mar Drυgs. 2020 Aug 17;18(8):429.

  Comparison of Physicochemical Characteristics and Macrophage Immunostimulatory Activities of Polysaccharides from Chlamys farreri
  Streptomycin sulfate purchased from AbMole

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  Plants (Basel). 2020 Aug 28;9(9):1111.

  Plukenetia huayllabambana Fruits: Analysis of Bioactive Compounds, Antibacterial Activity and Relative Action Mechanisms
  Streptomycin sulfate purchased from AbMole

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  Sci Rep. 2020 Jul 31;10(1):12991.

  Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis
  Streptomycin sulfate purchased from AbMole

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  Fish Shellfish Immunol. 2020 Jul;102:480-488.

  Target of rapamycin signaling inhibits autophagy in sea cucumber Apostichopus japonicus
  Streptomycin sulfate purchased from AbMole

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  J Steroid Biochem Mol Biol. 2013 Nov;138:54-62.

  Effect of androgens on different breast cancer cells co-cultured with or without breast adipose fibroblasts
  Streptomycin sulfate purchased from AbMole

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  Sci Adv. 2020 Jul 10;6(28):eaba7260.

  A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
  Streptomycin sulfate purchased from AbMole

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  Pharmaceuticals (Basel). 2020 Mar 30;13(4):59.

  In Vitro Antibacterial and Antiproliferative Potential of Echinops lanceolatus Mattf. (Asteraceae) and Identification of Potential Bioactive Compounds
  Streptomycin sulfate purchased from AbMole

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  Cell Commun Signal. 2020 Feb 17;18(1):27.

  mTOR May Interact With PARP-1 to Regulate Visible Light-Induced Parthanatos in Photoreceptors
  Streptomycin sulfate purchased from AbMole

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  J Exp Clin Cancer Res. 2020 May 24;39(1):93.

  TFEB-NF-κB Inflammatory Signaling Axis: A Novel Therapeutic Pathway of Dihydrotanshinone I in Doxorubicin-Induced Cardiotoxicity
  Streptomycin sulfate purchased from AbMole

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  Br J Cancer. 2020 May;122(11):1673-1685.

  CSN6-TRIM21 Axis Instigates Cancer Stemness During Tumorigenesis
  Streptomycin sulfate purchased from AbMole

Customer Product Validations & Biological Datas

	Source	Pharmaceuticals 2020 Mar. Figure 1. Streptomycin (Abmole Bioscience, USA)
	Method	Vitro Antiproliferative Assays
	Cell Lines	HepG2
	Concentrations	-
	Incubation Time	48 h
	Results	At a fixed concentration of 100 g/mL, EL-MeOH and fractions from E. lanceolatus displayed antiproliferative activity depending on studied cells.

Chemical Information

Molecular Weight	581.57
Formula	C21H39N7O12
CAS Number	3810-74-0
Solubility (25°C)	Water 86 mg/mL
Storage	-20°C, protect from light, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sharma D,et.al. J Mol Biol Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome.