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Cat. No. M1738
Niltubacin Structure


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1mg USD 288  USD320 In stock
2mg USD 540  USD600 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Niltubacin, as an inactive derivative of Tubacinis, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6. Histone deacetylase 6 (HDAC6) is structurally and functionally unique among the 11 human zinc-dependent histone deacetylases. HDAC6-selective inhibitor tubacin significantly enhances cell death induced by the topoisomerase II inhibitors etoposide and doxorubicin and the pan-HDAC inhibitor SAHA (vorinostat) in transformed cells (LNCaP, MCF-7), an effect not observed in normal cells. The inactive analogue of tubacin, nil-tubacin, does not sensitize transformed cells to these anticancer agents.

Product Citations
Customer Product Validations & Biological Datas
Source J Cell Biochem (2017). Figure 5. Niltubacin (Abmole Bioscience Inc.)
Method Clonogenic survival assay
Cell Lines FEMX-I cell line
Concentrations 200 µm
Incubation Time 24 h
Results This effect was specific for tubacin, as TSA, niltubacin and ACY-1215 did not inhibit the formation of cell aggregates. Similar effects were observed in Caco-2 cell line (Supplementary Fig. S5).
Source J Cell Biochem (2017). Figure 2. Niltubacin (Abmole Bioscience Inc.)
Method Cell Aggregation Assay
Cell Lines FEMX-I cell line
Incubation Time 24 h
Results The effect was specific, as the inactive analog of tubacin, niltubacin, at the same concentration did not increase CD133, CD9, or b-actin levels (Fig. 2c).
Source Mol. Cell. Biol. (2016). Figure 9. Tubacin and Niltubacin for animal studies were obtained from AbMole Bioscience Inc. (Houston, TX)
Method BK-SS mice
Cell Lines
Concentrations 0.5mg/kg i.p.
Incubation Time 5 or 10 or 30 days
Results These drug regimens showed a time dependent reduction of PlGF (Fig. 9C) and ET-1 (Fig. 9D) in plasma, compared to Niltubacin. The 30 day drug treatment effectively reduced plasma levels of PlGF by ~60% (p <0.001, Fig. 9C) and plasma levels of ET-1 by ~60% (p<0.001, Fig. 9D).
Source Mol. Cell. Biol. (2016). Figure 7. Tubacin and Niltubacin for animal studies were obtained from AbMole Bioscience Inc. (Houston, TX)
Cell Lines HMEC-1 cells
Concentrations 5 µM
Incubation Time 30 min
Results Taken together, these data showed PlGF induced chromatin condensation to repress DNM3os transcription, while Tubacin prevented the repressive effect following PlGF signaling.
Source Mol. Cell. Biol. (2016). Figure 6. Tubacin and Niltubacin for animal studies were obtained from AbMole Bioscience Inc. (Houston, TX)
Method qRT-PCR and reporter luciferase activity
Cell Lines HMEC-1 cells
Concentrations 5 µM
Incubation Time 30 min
Results We concluded that HDAC6 required functional ATF3 binding sites in the DNM3os promoter and any antagonism of PlGF effects by Tubacin was not due to a general effect on transcription of the endogenous DNM3os gene or the wt DNM3os reporter construct.
Cell Experiment
Cell lines Raji cells
Preparation method Cell adhesion assay Prior to SDF-1α (100 ng/ml) stimulation, Raji cells were treated with DMSO, NaB (1 μM), or tubacin (1 μM) for 3 hours. Then cells were plated into a 96-well plate which were precoated with Fibronectin (50 ng/ml) to allow cell adherence for 30 minutes. Subsequently cells were washed with PBS three times to remove the non-adherent cells, and adherent cells were measured by CellTiter-Glo luminescent cell viability assay kit.
Concentrations 1μM
Incubation time 3h
Animal Experiment
Animal models PLD animal model 3-week-old PCK rats
Formulation saline
Dosages 30 mg/kg body
Administration intraperitoneally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 706.85
Formula C41H42N2O7S
CAS Number
Purity >98%
Solubility DMSO ≥5 mg/mL
Storage at -20°C

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents.
Namdar et al. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20003-8. PMID: 21037108.

Histone deacetylase 6 interacts with the microtubule-associated protein tau.
Ding et al. J Neurochem. 2008 Sep;106(5):2119-30. PMID: 18636984.

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Abmole Inhibitor Catalog 2017

Keywords: Niltubacin, MAZ-1391 supplier, HDAC, inhibitors

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