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Ionomycin (Calcium salt)

Cat. No. M3807
Ionomycin (Calcium salt) Structure
Synonym:

Calcium ionomycin

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1mg USD 190  USD190 In stock
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Biological Activity

Ionomycin causes a rapid rise in cytosolic Ca2+ that is due to both a release of cytosolic Ca2+ stores and Ca2+ influx. Ionomycin also activates (2 microM) and primes (20-200 nM) the PMN oxidase. Ionomycin is shown to be an effective ionophore for Ca2+ in rat liver mitochondria. DNA and protein analysis in Ionomycin (SQ23377)-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Three hours after addition of ionomycin, the percentage of early apoptotic cells approximately doubles. Necrosis could be detected in ~1-5% of the Ionomycin (SQ23377) treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake.

Product Citations
Chemical Information
Molecular Weight 747.07
Formula C41H71O9.Ca
CAS Number 56092-82-1
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage -20°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gil-Parrado S, et al. J Biol Chem. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.

[2] Chatila T, et al. J Immunol. Mechanisms of T cell activation by the calcium ionophore ionomycin.

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Keywords: Ionomycin (Calcium salt), Calcium ionomycin supplier, Calcium Channel, inhibitors, activators


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