All AbMole products are for research use only, cannot be used for human consumption.
Ionomycin causes a rapid rise in cytosolic Ca2+ that is due to both a release of cytosolic Ca2+ stores and Ca2+ influx. Ionomycin also activates (2 microM) and primes (20-200 nM) the PMN oxidase. Ionomycin is shown to be an effective ionophore for Ca2+ in rat liver mitochondria. DNA and protein analysis in Ionomycin (SQ23377)-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Three hours after addition of ionomycin, the percentage of early apoptotic cells approximately doubles. Necrosis could be detected in ~1-5% of the Ionomycin (SQ23377) treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake.
Adv Sci (Weinh). 2024 Jan;11(4):e2305175.
Single-Cell Atlas of Human Ovaries Reveals The Role Of The Pyroptotic Macrophage in Ovarian Aging
Ionomycin (Calcium salt) purchased from AbMole
Nat Commun. 2023 Mar 23;14(1):1606.
Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field
Ionomycin (Calcium salt) purchased from AbMole
Neurochem Res. 2023 Feb;48(2):447-457.
Ca2+ Regulates Autophagy Through CaMKKβ/AMPK/mTOR Signaling Pathway in Mechanical Spinal cord Injury: An in vitro Study
Ionomycin (Calcium salt) purchased from AbMole
Hematol Oncol. 2023 Jul 26.
Magnesium enhances the graft-versus-tumor effect of donor lymphocytic infusion on hematologic malignancies
Ionomycin (Calcium salt) purchased from AbMole
Front Immunol. 2022 May 23;13:866638.
A Novel STAT3 Gain-of-Function Mutation in Fatal Infancy-Onset Interstitial Lung Disease
Ionomycin (Calcium salt) purchased from AbMole
| Molecular Weight | 747.07 |
| Formula | C41H71O9.Ca |
| CAS Number | 56092-82-1 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage | -20°C, dry, protect from light, sealed |
[2] Chatila T, et al. J Immunol. Mechanisms of T cell activation by the calcium ionophore ionomycin.
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