MPTP hydrochloride blocked nerve-evoked twitches in a concentration (1-200 microM)-dependent manner. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||Water: ≥ 55 mg/mL|
Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models.
Sun XL, et al. J Neuroinflammation. 2016 Jul 8;13(1):180. PMID: 27391369.
Protocol for the MPTP mouse model of Parkinson's disease
Vernice Jackson-Lewis, et al. Nat Protoc. 2007;2(1):141-51. PMID: 17401348.
Kinetics of nigral degeneration in a chronic model of MPTP-treated mice
E Bezard, et al. Neurosci Lett. 1997 Sep 26;234(1):47-50. PMID: 9347943.
Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat.
Desole MS, et al. Pharmacol Biochem Behav. 1996 Jun;54(2):377-83. PMID: 8743598.
Potentiation of MPTP by 4-phenylpyridine on the neuromuscular blockade in mouse phrenic nerve-diaphragm.
Hsu KS, et al. Neuropharmacology. 1993 Sep;32(9):877-83. PMID: 7901791.
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