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MPTP HCl

Cat. No. M9049
MPTP HCl Structure
Synonym:

MPTP hydrochloride; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride

Size Price Availability Quantity
5mg USD 30  USD30 In stock
10mg USD 55  USD55 In stock
25mg USD 100  USD100 In stock
50mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

MPTP hydrochloride blocked nerve-evoked twitches in a concentration (1-200 microM)-dependent manner. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.

Product Citations
Chemical Information
Molecular Weight 209.72
Formula C12H16ClN
CAS Number 23007-85-4
Solubility (25°C) Water: ≥ 55 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sun XL, et al. J Neuroinflammation. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models.

[2] Vernice Jackson-Lewis, et al. Nat Protoc. Protocol for the MPTP mouse model of Parkinson's disease

[3] E Bezard, et al. Neurosci Lett. Kinetics of nigral degeneration in a chronic model of MPTP-treated mice

[4] Desole MS, et al. Pharmacol Biochem Behav. Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat.

[5] Hsu KS, et al. Neuropharmacology. Potentiation of MPTP by 4-phenylpyridine on the neuromuscular blockade in mouse phrenic nerve-diaphragm.

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Keywords: MPTP HCl, MPTP hydrochloride; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride supplier, Dopamine Receptor, inhibitors, activators


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