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MPTP hydrochloride blocked nerve-evoked twitches in a concentration (1-200 microM)-dependent manner. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.
Curr Issues Mol Biol. 2024 Sep 12;46(9):10038-10064.
Disulfidptosis: A New Target for Parkinson’s Disease and Cancer
MPTP HCl purchased from AbMole
BMC Complement Med Ther. 2023 Jul 1;23(1):218.
Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis
MPTP HCl purchased from AbMole
Int J Neurosci. 2022 Jul 18;1-9.
Sinomenine exerts a neuroprotective effect on PD mouse model through inhibiting PI3K/AKT/mTOR pathway to enhance autophagy
MPTP HCl purchased from AbMole
| Molecular Weight | 209.72 |
| Formula | C12H16ClN |
| CAS Number | 23007-85-4 |
| Solubility (25°C) | Water ≥ 55 mg/mL DMSO ≥ 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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