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MPTP HCl

Cat. No. M9049
MPTP HCl Structure
Synonym:

MPTP hydrochloride

Size Price Availability Quantity
10mM*1mL USD 61.2  USD68 In stock
10mg USD 54  USD60 In stock
25mg USD 90  USD100 In stock
50mg USD 144  USD160 In stock
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Quality Control
Biological Activity

MPTP hydrochloride blocked nerve-evoked twitches in a concentration (1-200 microM)-dependent manner. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 209.72
Formula C12H16ClN
CAS Number 23007-85-4
Purity 100.0%
Solubility Water: ≥ 55 mg/mL
Storage at -20°C
References

Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models.
Sun XL, et al. J Neuroinflammation. 2016 Jul 8;13(1):180. PMID: 27391369.

Protocol for the MPTP mouse model of Parkinson's disease
Vernice Jackson-Lewis, et al. Nat Protoc. 2007;2(1):141-51. PMID: 17401348.

Kinetics of nigral degeneration in a chronic model of MPTP-treated mice
E Bezard, et al. Neurosci Lett. 1997 Sep 26;234(1):47-50. PMID: 9347943.

Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat.
Desole MS, et al. Pharmacol Biochem Behav. 1996 Jun;54(2):377-83. PMID: 8743598.

Potentiation of MPTP by 4-phenylpyridine on the neuromuscular blockade in mouse phrenic nerve-diaphragm.
Hsu KS, et al. Neuropharmacology. 1993 Sep;32(9):877-83. PMID: 7901791.

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Keywords: MPTP HCl, MPTP hydrochloride supplier, Dopamine Receptor, inhibitors

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