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Alizapride hydrochloride

Cat. No. M2372
Alizapride hydrochloride Structure
Size Price Availability Quantity
50mg USD 80  USD80 In stock
100mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Alizapride hydrochloride is a dopamine receptor antagonist used for the theropy of nausea and vomiting.

Chemical Information
Molecular Weight 351.83
Formula C16H21N5O2.HCl
CAS Number 59338-87-3
Form Solid
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mlanie Closset, et al. Long term stability of an admixture of alizapride and ondansetron in 0.9% sodium chloride solution polyolefin bags stored at 5±3°C

[2] Geertrui Dewinter, et al. Alizapride and ondansetron for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic gynaecological surgery: A double-blind, randomised, placebo-controlled noninferiority study

[3] A Athanasopoulos, et al. Long-term stability of the hydrochlorides of tramadol and alizapride in dextrose 5% polyolefin bag at 5+/-3 degrees C

[4] L H Booij, et al. Alizapride in prevention of postoperative nausea and vomiting

[5] H Bleiberg, et al. Activity of a new antiemetic agent: alizapride. A randomized double-blind crossover controlled trial

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