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Dopamine Receptor Dopamine Receptor

Inhibitors

Cat.No.  Name Information
M5686 Haloperidol Haloperidol is a potent dopamine D2 receptor antagonist.
M21180 TAK-906 TAK-906 is a peripherally restricted, non-BBB permeable molecule that targets the posterior region of the stomach and vomiting center for the study of gastric cramps.
M21067 LY3154885 LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM).
M20979 ONC206 ONC206 is a selective antagonist of dopamine D2-like receptor (DRD2) and has broad-spectrum anti-tumor activity.
M20668 Trifluoperazine Trifluoperazine is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor.
M20665 Tiapride Hydrochloride Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.
M20447 Melitracen hydrochloride Melitracen hydrochloride is a potential dopamine D1/2 receptor antagonist which has antidepressant properties.
M20407 Piribedil Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
M20395 Tetrabenazine (Xenazine) Tetrabenazine(Nitoman, Xenazine) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2 Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2.
M13954 Zuclopenthixol Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist.
M13953 Tetrahydropalmatine hydrochloride Tetrahydropalmatine (DL-Tetrahydropalmatine) hydrochloride possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.
M13952 Tetrahydropalmatine Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.
M13951 Sultopride hydrochloride Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor.
M13950 Quinpirole Hydrochloride Quinpirole Hydrochloride ((-)-LY 171555) is a high-affinity agonist of dopamine D2/D3 receptor.
M13949 Nomifensine Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.
M13948 Neuromedin N Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.
M11167 A-381393 A-381393 IS AN EFFECTIVE, SELECTIVE, AND BLOOD-BRAIN BARRIER-PERMEABLE dopamine D4 receptor Antagonist, dopamine D for humans4.4,D4.2 AND D4.7 receptors Ki The values are 1.5, 1.9, and 1.6 nM, respectively, with selectivity being D1,D2,D3,D5 MORE THAN 2700 TIMES THE DOPAMINE RECEPTOR. A-381393 VS. 5-HT2A MODERATE SELECTIVITY, Ki The value is 370 nM.
M10724 Pridopidine Pridopidine is a dopamine (DA) stabilizer that acts as a low-affinity dopamine D2 receptor (D2R) antagonist. Pridopidine high affinity acts on sigma 1 receptor (S1R),Ki Values of 70 to 80 nM are approximately 100 times higher than their affinity for D2R.
M10494 ML417 ML417 is a highly selective and brain penetrant D3 dopamine receptor (D3R) agonist, with EC50 of 38 nM.
M9601 Cariprazine Cariprazine is a D2 and D3 receptor partial agonist, with high selectivity towards the D3 receptor.
M9482 PD-168077 maleate PD-168077 maleate is a potent D4 dopamine receptor agonist (Ki = 8.7 nM), with > 400-fold and > 300-fold selectivity over D2 / D3 subtypes, respectively.



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