| Cat.No. | Name | Information |
|---|---|---|
| M9049 | MPTP HCl | MPTP is dehydrogenated in nigrostriatal cells to generate MPP+, which in turn inhibits mitochondrial complex enzymes and contributes to cell death. It can be used to construct animal models of Parkinson's disease. |
| M5686 | Haloperidol | Haloperidol is a potent dopamine D2 receptor antagonist. |
| M2472 | Bromocriptine Mesylate | Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes. |
| M55365 | Apomorphine hydrochloride hemihydrate | Apomorphine hydrochloride hemihydrate is a dopamine D2 agonist. |
| M45388 | Paliperidone palmitate | Paliperidone palmitate is the ester precursor compound of Paliperidone, a potent dopamine antagonist and 5-HT2A antagonist. Paliperidone is a potent dopamine antagonist and 5-HT2A antagonist. |
| M40730 | Solriamfetol hydrochloride | Solriamfetol hydrochloride is a selective dopamine and norepinephrine reuptake inhibitor that may be used in studies related to idiopathic narcolepsy and other narcolepsy syndromes. |
| M29005 | Ecopipam hydrochloride | Ecopipam (SCH 39166) hydrochloride is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrochloride shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrochloride can be used for the research of schizophrenia and obesity. |
| M28766 | Tavapadon | Tavapadon (PF-06649751) is a potentially best-in-class, orally active, highly selective dopamine D1/D5 receptor partial agonist for studies related to Parkinson's disease (PD). |
| M28383 | Thiethylperazine | Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects. |
| M28018 | Brilaroxazine | Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki=1.5 nM) and 5-HT2A (Ki=2.5 nM), and has antagonist activity at 5-HT2B (Ki=0.19 nM), and 5-HT7 (Ki=2.7 nM) receptors. |
| M27890 | Thiethylperazine dimaleate | Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects. |
| M21844 | Acetophenazine dimaleate | Acetophenazine dimaleate primarily blocks dopamine D2 receptors in the brain. Acetophenazine dimaleate can be used for the research of psychotic disorders. |
| M20979 | ONC206 | ONC206 is a selective antagonist of dopamine D2-like receptor (DRD2) and has broad-spectrum anti-tumor activity. |
| M20535 | Chlorpromazine | Chlorpromazine is an orally active, blood-brain barrier-transparent D2 dopamine receptors and 5-HT2A antagonist. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM). |
| M13953 | Tetrahydropalmatine hydrochloride | Tetrahydropalmatine (DL-Tetrahydropalmatine) hydrochloride possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats. |
| M13949 | Nomifensine | Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters. |
| M11167 | A-381393 | A-381393 IS AN EFFECTIVE, SELECTIVE, AND BLOOD-BRAIN BARRIER-PERMEABLE dopamine D4 receptor Antagonist, dopamine D for humans4.4，D4.2 AND D4.7 receptors Ki The values are 1.5, 1.9, and 1.6 nM, respectively, with selectivity being D1，D2，D3，D5 MORE THAN 2700 TIMES THE DOPAMINE RECEPTOR. A-381393 VS. 5-HT2A MODERATE SELECTIVITY, Ki The value is 370 nM. |
| M10724 | Pridopidine | Pridopidine is a dopamine (DA) stabilizer that acts as a low-affinity dopamine D2 receptor (D2R) antagonist. Pridopidine high affinity acts on sigma 1 receptor (S1R),Ki Values of 70 to 80 nM are approximately 100 times higher than their affinity for D2R. |
| M10494 | ML417 | ML417 is a highly selective and brain penetrant D3 dopamine receptor (D3R) agonist, with EC50 of 38 nM. |
| M9601 | Cariprazine | Cariprazine is a D2 and D3 receptor partial agonist, with high selectivity towards the D3 receptor. |
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