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L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors.
| Molecular Weight | 326.82 |
| Formula | C18H19ClN4 |
| CAS Number | 158985-00-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light |
[5] T A Baskerville, et al. Eur J Neurosci. Dopamine-oxytocin interactions in penile erection
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