Inhibitors
Cat.No. | Name | Information |
---|---|---|
M5686 | Haloperidol | Haloperidol is a potent dopamine D2 receptor antagonist. |
M5410 | Amisulpride | Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. |
M5350 | (+,-)-Octopamine | Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. |
M5198 | Fluphenazine dihydrochloride | Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. |
M4942 | Metoclopramide hydrochloride hydrate | Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic. |
M3818 | Rotigotine Hydrochloride | Rotigotine Hydrochloride (N-0923 Hydrochloride) is a pure agonist of the dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor.Ki 值分别为 0.71 nM (dopamine D3 receptor),4-15 nM (D2,D5,D4 receptors),83 nM (dopamine D1 receptor)。 |
M3785 | Flupenthixol dihydrochloride | Flupenthixol dihydrochloride is a dopamine receptor antagonist which acts as a Neuroleptic agent as well as an antipsychotic. |
M3675 | Rotigotine | Rotigotine (N-0437; N-0923) is a dopamine receptor agonist, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor.Ki 值分别为 0.71 nM (dopamine D3 receptor),4-15 nM (D2,D5,D4 receptors),83 nM (dopamine D1 receptor)。 |
M3674 | Metoclopramide | Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic. |
M3586 | Pramipexole dihydrochloride Monohydrate | Pramipexole dihydrochloride Monohydrate is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM. |
M3338 | Domperidone | Domperidone is a dopamine blocker and an antidopaminergic reagent. |
M3287 | PD128907 hydrochloride | PD 128907 hydrochloride is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
M3250 | Vanoxerine dihydrochloride | Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent and selective dopamine receptor inhibitor. |
M3246 | Amfebutamone hydrochloride | Amfebutamone hydrochloride is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4μM for the reuptake of dopamine and norepinephrine, respectively |
M3242 | Sumanirole Maleate | Sumanirole maleate is a highly selective dopamine D2 receptor agonist with binding affinity of 9 nM and EC50 of about 46 nM, exhibits >200-fold selectivity over the other dopamine receptor subtypes. |
M3165 | Prochlorperazine dimaleate | Prochlorperazine dimaleate is a D2 dopamine receptor antagonist. |
M3088 | Triflupromazine hydrochloride | Triflupromazine hydrochloride is a member of a family of phenothiazine compounds that are dopamine D1/D2 receptor antagonists. |
M3087 | Trifluoperazine dihydrochloride | Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. |
M2987 | Ropinirole hydrochloride | Ropinirole a selective dopamine D2 receptors inhibitor with IC50 of 29 nM. |
M2945 | Pimozide | Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. |
M2936 | Phenothiazine | Phenothiazine is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain. |
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