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Prochlorperazine dimaleate salt

Cat. No. M5900
Prochlorperazine dimaleate salt Structure
Synonym:

Prochlorperazin, Compazine, Capazine, Stemetil

Size Price Availability Quantity
10mg USD 108  USD120 In stock
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Quality Control
Biological Activity

Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 606.09
Formula C20H24ClN3S.C8H8O8
CAS Number 84-02-6
Purity 100.0%
Solubility 74 mg/mL warmed in DMSO
Storage at -20°C
References

Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients.
Tashiro M, et al. Clin Chim Acta. 2014 Feb 15;429:175-80. PMID: 24360851.

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Keywords: Prochlorperazine dimaleate salt, Prochlorperazin, Compazine, Capazine, Stemetil supplier, Dopamine Receptor, inhibitors

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