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Azaperone

Cat. No. M2415
Azaperone Structure
Size Price Availability Quantity
200mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic compound with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. Azaperone (2.2 mg/kg i.m) decreases total fighting from 309.8 min for saline to 189.6 min in pigs. Azaperone (103.1 mg) combined with Butorphanol (69.3 mg) produces adequate muscle relaxation and apparently adequate analgesia for minor surgical interferences, including abdominal laparoscopy in a white rhinoceros with chronic renal disease.

Chemical Information
Molecular Weight 327.4
Formula C19H22FN3O
CAS Number 1649-18-9
Form Solid
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gonyou HW, et al. J Anim Sc. Effects of amperozide and azaperone on aggression and productivity of growing-finishing pigs.

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