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Cariprazine hydrochloride

Cat. No. M2494
Cariprazine hydrochloride Structure
Synonym:

RGH-188 HCl

Size Price Availability Quantity
10mg USD 60  USD60 In stock
25mg USD 95  USD95 In stock
50mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

Cariprazine hydrochloride is a dopamine D3-receptor-preferring partial agonist that exhibits high selectivity and affinity to dopamine D3 and D2(L/S) receptors with pKi 10.07 and 9.16/9.31, respectively.

Chemical Information
Molecular Weight 463.87
Formula C21H32Cl2N4O.HCl
CAS Number 1083076-69-0
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Aust Prescr. Cariprazine hydrochloride for schizophrenia

[2] Amber Edinoff, et al. Cariprazine to Treat Schizophrenia and Bipolar Disorder in Adults

[3] Renee-Marie Ragguett, et al. Cariprazine for the treatment of bipolar depression: a review

[4] Lakshmi N Yatham, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

[5] Karly P Garnock-Jones. Cariprazine: A Review in Schizophrenia

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