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Naxagolide

Cat. No. M1915
Naxagolide Structure
Synonym:

Dopazinol

Size Price Availability
10mg USD 480  USD480 Out of stock
50mg USD 1800  USD1800 Out of stock
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Quality Control & Documentation
Biological Activity

Naxagolide (Dopazinol) is a very potent and selective D2 agonist. Naxagolide is used for treatment of extrapyramidal disorders.

Chemical Information
Molecular Weight 247.34
Formula C15H21NO2
CAS Number 88058-88-2
Form Solid
Solubility (25°C) Ethanol
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Doris Payer, et al. What is the role of the D3 receptor in addiction? A mini review of PET studies with [(11)C]-(+)-PHNO

[2] E F Domino, et al. Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys

[3] B Bowery, et al. Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area

[4] J A Obeso, et al. Continuous dopaminergic stimulation in Parkinson disease

[5] C G Goetz, et al. Dopaminergic agonists in the treatment of Parkinson's disease

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Keywords: Naxagolide, Dopazinol supplier, Dopamine Receptor, inhibitors, activators


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