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SB 277011 Hydrochloride

Cat. No. M5854
SB 277011 Hydrochloride Structure
Size Price Availability Quantity
5mg USD 180  USD200 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SB 277011-A (a DRD3 selective antagonist) significantly reduced cue-induced reinstatement at all the doses tested, whereas there was no significant effect of BP 897 (a DRD3 partial agonist) on cue-induced reinstatement of nicotine-seeking or on nicotine-taking behaviour.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male, Long–Evans rats
Formulation
Dosages 1, 3 and 10 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 438.56
Formula C28H31ClN4O
CAS Number 215804-67-4
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

The selective dopamine D₃ receptor antagonist SB-277011-A significantly decreases binge-like consumption of ethanol in C57BL/J6 mice.
Rice OV, et al. Synapse. 2015 Jun;69(6):295-8. PMID: 25764479.

Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain.
Southam E, et al. Brain Res. 2007 May 29;1149:50-7. PMID: 17382304.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SB 277011 Hydrochloride supplier, Dopamine Receptor, inhibitors

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