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SB 277011-A (a DRD3 selective antagonist) significantly reduced cue-induced reinstatement at all the doses tested, whereas there was no significant effect of BP 897 (a DRD3 partial agonist) on cue-induced reinstatement of nicotine-seeking or on nicotine-taking behaviour.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Male, Long–Evans rats |
| Formulation | |
| Dosages | 1, 3 and 10 mg/kg |
| Administration | i.p. |
| Molecular Weight | 438.56 |
| Formula | C28H31ClN4O |
| CAS Number | 215804-67-4 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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