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Clebopride malate

Cat. No. M5525
Clebopride malate Structure
Size Price Availability Quantity
10mg USD 87  USD87 In stock
50mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Clebopride malate is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders.

Chemical Information
Molecular Weight 507.96
Formula C24H30ClN3O7
CAS Number 57645-91-7
Solubility (25°C) 34 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kawasaki H, et al. Rinsho Shinkeigaku. A case of respiratory dyskinesia due to clebopride malate

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