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Fluphenazine dihydrochloride

Cat. No. M5198
Fluphenazine dihydrochloride Structure
Synonym:

Fluphenazine 2HCl

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 36  USD40 In stock
100mg USD 49.5  USD55 In stock
200mg USD 67.5  USD75 In stock
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Quality Control
Biological Activity

Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. Fluphenazine 2HCl also inhibits Histamine H1 Receptor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 510.44
Formula C22H26F3N3OS.2HCl
CAS Number 146-56-5
Purity >99%
Solubility DMSO 60 mg/mL
Water 90 mg/mL
Storage -20°C, sealed
References

A comparative study of the anticholinesterase activity of several antipsychotic agents.
Nasello AG, et al. Pharmacol Biochem Behav. 2003 Jul;75(4):895-901. PMID: 12957233.

Behavioral effects of withdrawal of fluphenazine after long-term treatment.
Trzeciak HI, et al. Arzneimittelforschung. 1976;26(9):1697-700. PMID: 1036703.

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Keywords: Fluphenazine dihydrochloride, Fluphenazine 2HCl supplier, Dopamine Receptor, inhibitors

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