| Cat.No. | Name | Information |
|---|---|---|
| M9049 | MPTP HCl | MPTP is dehydrogenated in nigrostriatal cells to generate MPP+, which in turn inhibits mitochondrial complex enzymes and contributes to cell death. It can be used to construct animal models of Parkinson's disease. |
| M5686 | Haloperidol | Haloperidol is a potent dopamine D2 receptor antagonist. |
| M2472 | Bromocriptine Mesylate | Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes. |
| M55454 | Amisulpride-d5 | Amisulpride-d5 |
| M55438 | Paliperidone-d4 | Paliperidone-d4 |
| M55425 | Dopamine-d4 HCl | Dopamine-d4 HCl |
| M55365 | Apomorphine hydrochloride hemihydrate | Apomorphine hydrochloride hemihydrate is a dopamine D2 agonist. |
| M45388 | Paliperidone palmitate | Paliperidone palmitate is the ester precursor compound of Paliperidone, a potent dopamine antagonist and 5-HT2A antagonist. Paliperidone is a potent dopamine antagonist and 5-HT2A antagonist. |
| M44845 | D-Tetrahydropalmatine | D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis. |
| M40730 | Solriamfetol hydrochloride | Solriamfetol hydrochloride is a selective dopamine and norepinephrine reuptake inhibitor that may be used in studies related to idiopathic narcolepsy and other narcolepsy syndromes. |
| M29005 | Ecopipam hydrochloride | Ecopipam (SCH 39166) hydrochloride is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrochloride shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrochloride can be used for the research of schizophrenia and obesity. |
| M28766 | Tavapadon | Tavapadon (PF-06649751) is a potentially best-in-class, orally active, highly selective dopamine D1/D5 receptor partial agonist for studies related to Parkinson's disease (PD). |
| M28637 | L-745870 | L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors. |
| M28383 | Thiethylperazine | Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects. |
| M28018 | Brilaroxazine | Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki=1.5 nM) and 5-HT2A (Ki=2.5 nM), and has antagonist activity at 5-HT2B (Ki=0.19 nM), and 5-HT7 (Ki=2.7 nM) receptors. |
| M27890 | Thiethylperazine dimaleate | Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects. |
| M21844 | Acetophenazine dimaleate | Acetophenazine dimaleate primarily blocks dopamine D2 receptors in the brain. Acetophenazine dimaleate can be used for the research of psychotic disorders. |
| M20979 | ONC206 | ONC206 is a selective antagonist of dopamine D2-like receptor (DRD2) and has broad-spectrum anti-tumor activity. |
| M20535 | Chlorpromazine | Chlorpromazine is an orally active, blood-brain barrier-transparent D2 dopamine receptors and 5-HT2A antagonist. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM). |
| M20407 | Piribedil | Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
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