| Cat.No. | Name | Information |
|---|---|---|
| M5686 | Haloperidol | Haloperidol is a potent dopamine D2 receptor antagonist. |
| M9049 | MPTP HCl | MPTP is dehydrogenated in nigrostriatal cells to generate MPP+, which in turn inhibits mitochondrial complex enzymes and contributes to cell death. It can be used to construct animal models of Parkinson's disease. |
| M2472 | Bromocriptine Mesylate | Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes. |
| M3246 | Amfebutamone hydrochloride | Amfebutamone hydrochloride is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4μM for the reuptake of dopamine and norepinephrine, respectively |
| M3242 | Sumanirole Maleate | Sumanirole maleate is a highly selective dopamine D2 receptor agonist with binding affinity of 9 nM and EC50 of about 46 nM, exhibits >200-fold selectivity over the other dopamine receptor subtypes. |
| M3165 | Prochlorperazine dimaleate | Prochlorperazine dimaleate is a D2 dopamine receptor antagonist. |
| M3088 | Triflupromazine hydrochloride | Triflupromazine hydrochloride is a member of a family of phenothiazine compounds that are dopamine D1/D2 receptor antagonists. |
| M3087 | Trifluoperazine dihydrochloride | Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. |
| M3065 | Thioridazine hydrochloride | Thioridazine is a trifluoro-methyl phenothiazine derivative, which blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain. |
| M2988 | Ropinirole | Ropinirole is a dopamine agonist in non-ergoline compounds. |
| M2987 | Ropinirole hydrochloride | Ropinirole a selective dopamine D2 receptors inhibitor with IC50 of 29 nM. |
| M2945 | Pimozide | Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. |
| M2936 | Phenothiazine | Phenothiazine is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain. |
| M2925 | Pergolide mesylate | Pergolide mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist. |
| M2886 | Nomifensine Maleate | Nomifensine is a dopamine reuptake inhibitor that increases the amount of synaptic dopamine available to receptors by blocking dopamine's re-uptake transporter. |
| M2655 | Droperidol | Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system. |
| M2494 | Cariprazine hydrochloride | Cariprazine hydrochloride is a dopamine D3-receptor-preferring partial agonist that exhibits high selectivity and affinity to dopamine D3 and D2(L/S) receptors with pKi 10.07 and 9.16/9.31, respectively. |
| M2415 | Azaperone | Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic compound with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. |
| M2372 | Alizapride hydrochloride | Alizapride hydrochloride is a dopamine receptor antagonist used for the theropy of nausea and vomiting. |
| M1915 | Naxagolide | Naxagolide (Dopazinol) is a very potent and selective D2 agonist. |
| M1910 | Nepicastat hydrochloride | Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively. |
| M54825 | SV 156 | SV 156 is a potent and selective D2 dopamine receptor antagonist, with a Ki of 2.5 nM for hD2. SV 156 has approximately 40-fold binding selectivity for D2 dopamine receptors compared to the D3 receptor subtype. |
| M53201 | Cyclo(glycyl-L-leucyl) | Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. |
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