| Cat.No. | Name | Information |
|---|---|---|
| M5686 | Haloperidol | Haloperidol is a potent dopamine D2 receptor antagonist. |
| M9049 | MPTP HCl | MPTP is dehydrogenated in nigrostriatal cells to generate MPP+, which in turn inhibits mitochondrial complex enzymes and contributes to cell death. It can be used to construct animal models of Parkinson's disease. |
| M2472 | Bromocriptine Mesylate | Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes. |
| M20535 | Chlorpromazine | Chlorpromazine is an orally active, blood-brain barrier-transparent D2 dopamine receptors and 5-HT2A antagonist. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM). |
| M3927 | Tetrahydropalmatine | Tetrahydropalmatine (THP) is a natural compound isolated from Corydalis turtschaninovii. |
| M3818 | Rotigotine Hydrochloride | Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Ki of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor. |
| M3785 | Flupenthixol dihydrochloride | Flupenthixol dihydrochloride is a dopamine receptor antagonist which acts as a Neuroleptic agent as well as an antipsychotic. |
| M3675 | Rotigotine | Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. |
| M3674 | Metoclopramide | Metoclopramide is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. |
| M3592 | Chlorprothixene | Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively. |
| M3586 | Pramipexole dihydrochloride Monohydrate | Pramipexole dihydrochloride Monohydrate is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM. |
| M3339 | Pramipexole | Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. |
| M3338 | Domperidone | Domperidone is a dopamine blocker and an antidopaminergic reagent. |
| M3287 | PD128907 hydrochloride | PD 128907 hydrochloride is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
| M3255 | Levodopa | Levodopa (Sinemet) is an amino acid precursor of dopamine with antiparkinsonian properties. |
| M3250 | Vanoxerine dihydrochloride | Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). |
| M3246 | Amfebutamone hydrochloride | Amfebutamone hydrochloride is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4μM for the reuptake of dopamine and norepinephrine, respectively |
| M3242 | Sumanirole Maleate | Sumanirole maleate is a highly selective dopamine D2 receptor agonist with binding affinity of 9 nM and EC50 of about 46 nM, exhibits >200-fold selectivity over the other dopamine receptor subtypes. |
| M3165 | Prochlorperazine dimaleate | Prochlorperazine dimaleate is a D2 dopamine receptor antagonist. |
| M3088 | Triflupromazine hydrochloride | Triflupromazine hydrochloride is a member of a family of phenothiazine compounds that are dopamine D1/D2 receptor antagonists. |
| M3087 | Trifluoperazine dihydrochloride | Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. |
| M3065 | Thioridazine hydrochloride | Thioridazine is a trifluoro-methyl phenothiazine derivative, which blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain. |
| M2988 | Ropinirole | Ropinirole is a dopamine agonist in non-ergoline compounds. |
| M2987 | Ropinirole hydrochloride | Ropinirole a selective dopamine D2 receptors inhibitor with IC50 of 29 nM. |
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