Flupenthixol dihydrochloride is a non-selective antagonist at D1 and D2 receptors. Flupenthixol dihydrochloride is a antagonist at dopamine (D1-D5), serotonin (5-HT2), adrenergic (α1) and histamine (H1) receptors. Flupenthixol dihydrochloride has antipsychotic properties in vivo. A single-blind, parallel group, general practice study was carried out in 153 patients with mild to moderate depression to compare the efficacy and tolerability of flupenthixol dihydrochloride and dothiepin hydrochloride. Both drugs were well tolerated, although persistence of anticholinergic side-effects in the dothiepin group resulted in a trend favouring flupenthixol. One patient in the flupenthixol group attempted suicide by overdose but made a complete recovery.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Rapid assessment of choice between cocaine and food in rhesus monkeys: effects of environmental manipulations and treatment with d-amphetamine and flupenthixol.
Negus SS. Neuropsychopharmacology. 2003 May;28(5):919-31. PMID: 12637948.
Effects of remoxipride and some related new substituted salicylamides on rat brain receptors.
Hall H, et al. Acta Pharmacol Toxicol (Copenh). 1986 Jan;58(1):61-70. PMID: 2869639.
Depression in general practice: a comparison of flupenthixol dihydrochloride and dothiepin hydrochloride.
Dwivedi VS, et al. Curr Med Res Opin. 1990;12(3):191-7. PMID: 2272193.
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