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Flupenthixol dihydrochloride

Cat. No. M3785
Flupenthixol dihydrochloride Structure
Synonym:

Flupenthixol 2HCl

Size Price Availability Quantity
10mg USD 120  USD120 In stock
50mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Flupenthixol dihydrochloride is a non-selective antagonist at D1 and D2 receptors. Flupenthixol dihydrochloride is a antagonist at dopamine (D1-D5), serotonin (5-HT2), adrenergic (α1) and histamine (H1) receptors. Flupenthixol dihydrochloride has antipsychotic properties in vivo. A single-blind, parallel group, general practice study was carried out in 153 patients with mild to moderate depression to compare the efficacy and tolerability of flupenthixol dihydrochloride and dothiepin hydrochloride. Both drugs were well tolerated, although persistence of anticholinergic side-effects in the dothiepin group resulted in a trend favouring flupenthixol. One patient in the flupenthixol group attempted suicide by overdose but made a complete recovery.

Chemical Information
Molecular Weight 507.44
Formula C23H25F3N2OS.2HCl
CAS Number 51529-01-2
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Negus SS. Neuropsychopharmacology. Rapid assessment of choice between cocaine and food in rhesus monkeys: effects of environmental manipulations and treatment with d-amphetamine and flupenthixol.

[2] Hall H, et al. Acta Pharmacol Toxicol (Copenh). Effects of remoxipride and some related new substituted salicylamides on rat brain receptors.

[3] Dwivedi VS, et al. Curr Med Res Opin. Depression in general practice: a comparison of flupenthixol dihydrochloride and dothiepin hydrochloride.

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