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PD128907 hydrochloride

Cat. No. M3287
PD128907 hydrochloride Structure
Size Price Availability Quantity
5mg USD 81  USD90 In stock
10mg USD 126  USD140 In stock
50mg USD 414  USD460 In stock
100mg USD 612  USD680 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

PD 128907 hydrochloride is a compound used in scientific research which acts as a potent and selective agonist for the dopamine D2 and D3 receptors. It is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release, as well as release of other neurotransmitters. In animal studies it has been shown to reduce toxicity from cocaine overdose, and may be useful in the development of medical treatments for this condition in humans.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Mouse
Formulation Water, with sonication
Dosages 3 mg/kg
Administration 3 mg/kg
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 285.77
Formula C14H19NO3.HCl
CAS Number 112960-16-4
Purity >98%
Solubility DMSO 10 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PD128907 hydrochloride supplier, Dopamine Receptor, inhibitors

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