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PD 128907 hydrochloride is a compound used in scientific research which acts as a potent and selective agonist for the dopamine D2 and D3 receptors. It is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release, as well as release of other neurotransmitters. In animal studies it has been shown to reduce toxicity from cocaine overdose, and may be useful in the development of medical treatments for this condition in humans.
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| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | Mouse |
| Formulation | Water, with sonication |
| Dosages | 3 mg/kg |
| Administration | 3 mg/kg |
| Molecular Weight | 285.77 |
| Formula | C14H19NO3.HCl |
| CAS Number | 112960-16-4 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Dopamine Receptor Products |
|---|
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AJ-76 ((+)-AJ 76; (1S,2R)-AJ 76) is a dopamine autoreceptor antagonist. |
| A-412997
A-412997 is a selective Dopamine D4 agonist with Ki values of 12 and 7.9 nM for the rat and human receptors. |
| SKF 81297
SKF 81297 is a potent and selective dopamine D1 receptor agonist. |
| GBR 12783
GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. |
| RMI-61140
RMI-61140 is an orally active neuroleptics. |
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