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Tetrahydropalmatine has been shown to have analgesic effects and may benefit research into heart disease and liver damage. It is a voltage-activated l-type calcium and potassium channel blocker. It has also shown potential in the treatment of addiction to cocaine and opioid compounds, and preliminary human studies have shown promising results. THP treatment significantly increased the activity of key MyoD activating myotropin kinases p38MAPK and Akt. THP treatment restored myoduct formation in C2C12-deficient cells by activating p38MAPK. THP enhanced myOd-mediated transformation and differentiation of 10T1/2 fibroblasts into myoblasts. Tetrahydropalmatine may have a potential research candidate to prevent fibrosis and improve muscle regeneration and repair.
| Molecular Weight | 355.43 |
| Formula | C21H25NO4 |
| CAS Number | 10097-84-4 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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