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Tetrahydropalmatine

Cat. No. M3927
Tetrahydropalmatine Structure
Size Price Availability Quantity
10mg USD 80  USD80 In stock
50mg USD 120  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tetrahydropalmatine has been shown to have analgesic effects and may benefit research into heart disease and liver damage. It is a voltage-activated l-type calcium and potassium channel blocker. It has also shown potential in the treatment of addiction to cocaine and opioid compounds, and preliminary human studies have shown promising results. THP treatment significantly increased the activity of key MyoD activating myotropin kinases p38MAPK and Akt. THP treatment restored myoduct formation in C2C12-deficient cells by activating p38MAPK. THP enhanced myOd-mediated transformation and differentiation of 10T1/2 fibroblasts into myoblasts. Tetrahydropalmatine may have a potential research candidate to prevent fibrosis and improve muscle regeneration and repair.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 355.43
Formula C21H25NO4
CAS Number 10097-84-4
Purity >98%
Solubility
Storage at -20°C
References

[1] Lee SJ, et al. Biochem Biophys Res Commun. Tetrahydropalmatine promotes myoblast differentiation through activation of p38MAPK and MyoD.

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