Chlorprothixene is a typical antipsychotic compound of the thioxanthene class and was the first of the series to be synthesized. Chlorprothixene exerts strong antagonism at the following receptors: 5-HT2, D1, D2, D3, H1,mACh, α1-adrenergic.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | B6.129P2 (CF/3)-CftrTgH(neoim)Hgu (abbreviated CFMHH) congenic mice. |
| Formulation | Dissolved in 0.9% NaCl solution, final concentration 8 mg/L |
| Dosages | 1 mL every time |
| Administration | Five 10-minute inhalations, every 12 hours |
| Molecular Weight | 315.86 |
| Formula | C18H18ClNS |
| CAS Number | 113-59-7 |
| Form | Solid |
| Solubility (25°C) | Ethanol 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Herbert Kferstein, et al. Chlorprothixene in bodies after exhumation
[5] No authors listed. Can J Psychiatr Nurs. Chlorprothixene--Taractan
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