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Metoclopramide is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide increases peristalsis of the jejunum and duodenum, increases tone and amplitude of gastric contractions, and relaxes the pyloric sphincter and duodenal bulb, while simultaneously increasing lower esophageal sphincter tone.
| Molecular Weight | 299.80 |
| Formula | C14H22ClN3O2 |
| CAS Number | 364-62-5 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 4°C, protect from light |
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