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Metoclopramide

Cat. No. M3674
Metoclopramide Structure
Size Price Availability Quantity
100mg USD 70  USD70 In stock
500mg USD 140  USD140 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Metoclopramide appears to be a promising candidate for the treatment of patients with intractable hiccups, with mild adverse events. Metoclopramide nasal spray offers better symptom control than metoclopramide oral tablet in diabetic patients with symptoms of gastroparesis. Metoclopramide increases peristalsis of the jejunum and duodenum, increases tone and amplitude of gastric contractions, and relaxes the pyloric sphincter and duodenal bulb, while simultaneously increasing lower esophageal sphincter tone.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 299.80
Formula C14H22ClN3O2
CAS Number 364-62-5
Purity >98%
Solubility DMSO
Storage at -20°C
References

[1] Wang T, et al. Intern Med J. Metoclopramide for patients with intractable hiccups: A multi-center, randomized, controlled pilot study.

[2] Parkman HP, et al. Neurogastroenterol Motil. Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet.

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  Catalog
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Keywords: Metoclopramide supplier, Dopamine Receptor, inhibitors

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