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Levodopa (Sinemet) is an amino acid precursor of dopamine with antiparkinsonian properties. Dopamine is converted from levodopa (Sinemet) by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson’s disease.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 197.19 |
| Formula | C9H11NO4 |
| CAS Number | 59-92-7 |
| Solubility (25°C) | 0.1 M HCL: 10 mg/mL Water 0.5 mg/mL |
| Storage | 2-8°C, sealed |
[2] Robert A Hauser. Levodopa: past, present, and future
[3] Giovanni Abbruzzese. Optimising levodopa therapy
[4] Stanley Fahn. The history of dopamine and levodopa in the treatment of Parkinson's disease
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