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Bromocriptine Mesylate

Cat. No. M2472
Bromocriptine Mesylate Structure
Synonym:

CB-154

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
25mg USD 75  USD75 In stock
50mg USD 90  USD90 In stock
100mg USD 110  USD110 In stock
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Quality Control & Documentation
Biological Activity

Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.

Product Citations
Chemical Information
Molecular Weight 750.7
Formula C32H40BrN5O5.CH4O3S
CAS Number 22260-51-1
Solubility (25°C) DMSO ≥ 50 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Maka Siamashvili, et al. Late phase completed clinical trials investigating bromocriptine mesylate quick release as treatment of type 2 diabetes mellitus

[2] Mary Courtney Moore, et al. Bromocriptine mesylate improves glucose tolerance and disposal in a high-fat-fed canine model

[3] Christy M Weiland, et al. Bromocriptine mesylate (Cycloset) for type 2 diabetes mellitus

[4] Masafumi Matsuda. Bromocriptine

[5] Jessica L Kerr, et al. Bromocriptine mesylate for glycemic management in type 2 diabetes mellitus

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Keywords: Bromocriptine Mesylate, CB-154 supplier, Dopamine Receptor, inhibitors, activators


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