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Amfebutamone (Bupropion) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4uM for the reuptake of dopamine and norepinephrine, respectively. Its primary pharmacological action is Norepinephrine-dopamine reuptake inhibition. It binds selectively to the dopamine transporter, but its behavioural effects have often been attributed to its inhibition of norepinephrine reuptake. It also acts as a nicotinic acetylcholine receptor antagonist.
| Molecular Weight | 276.2 |
| Formula | C13H18ClNO.HCl |
| CAS Number | 31677-93-7 |
| Solubility (25°C) | DMSO 8 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Drug Ther Bull. Naltrexone/bupropion for obesity
[2] S R Khan, et al. Bupropion Hydrochloride
[5] J P Feighner. Mechanism of action of antidepressant medications
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