Prochlorperazine dimaleate is a D2 receptor antagonist. Prochlorperazine dimaleate also interacts with 5-HT3 and nAChR. Prochlorperazine dimaleate displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Prochlorperazine induces central antinociception mediated by the muscarinic system.
Ghelardini C, et al. Pharmacol Res. 2004 Sep;50(3):351-8. PMID: 15225680.
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