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Prochlorperazine dimaleate

Cat. No. M3165
Prochlorperazine dimaleate Structure
Size Price Availability Quantity
200mg USD 135  USD150 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Prochlorperazine dimaleate is a D2 receptor antagonist. Prochlorperazine dimaleate also interacts with 5-HT3 and nAChR. Prochlorperazine dimaleate displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 606.09
Formula C20H24ClN3S.C8H8O8
CAS Number 1984-2-6
Purity >98%
Solubility DMSO
Storage at -20°C
References

Prochlorperazine induces central antinociception mediated by the muscarinic system.
Ghelardini C, et al. Pharmacol Res. 2004 Sep;50(3):351-8. PMID: 15225680.

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