| Cat.No. | Name | Information |
|---|---|---|
| M5686 | Haloperidol | Haloperidol is a potent dopamine D2 receptor antagonist. |
| M9049 | MPTP HCl | MPTP is dehydrogenated in nigrostriatal cells to generate MPP+, which in turn inhibits mitochondrial complex enzymes and contributes to cell death. It can be used to construct animal models of Parkinson's disease. |
| M2472 | Bromocriptine Mesylate | Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes. |
| M20535 | Chlorpromazine | Chlorpromazine is an orally active, blood-brain barrier-transparent D2 dopamine receptors and 5-HT2A antagonist. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM). |
| M5590 | Dopamine HCl | Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis. |
| M2945 | Pimozide | Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. |
| M2936 | Phenothiazine | Phenothiazine is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain. |
| M2925 | Pergolide mesylate | Pergolide mesylate is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for the research of Parkinson's disease and hyperprolactinaemia. |
| M2886 | Nomifensine Maleate | Nomifensine is a dopamine reuptake inhibitor that increases the amount of synaptic dopamine available to receptors by blocking dopamine's re-uptake transporter. |
| M2655 | Droperidol | Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system. |
| M2494 | Cariprazine hydrochloride | Cariprazine hydrochloride is a dopamine D3-receptor-preferring partial agonist that exhibits high selectivity and affinity to dopamine D3 and D2(L/S) receptors with pKi 10.07 and 9.16/9.31, respectively. |
| M2445 | Benztropine mesylate | Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM. Benztropine mesylate is a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects. Benztropine mesylate is also an anti-histamine agent and a dopamine re-uptake inhibitor. |
| M2415 | Azaperone | Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic compound with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. |
| M2372 | Alizapride hydrochloride | Alizapride hydrochloride is a dopamine receptor antagonist used for the theropy of nausea and vomiting. |
| M1915 | Naxagolide | Naxagolide (Dopazinol) is a very potent and selective D2 agonist. |
| M1910 | Nepicastat hydrochloride | Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively. |
| M56188 | AJ-76 | AJ-76 ((+)-AJ 76; (1S,2R)-AJ 76) is a dopamine autoreceptor antagonist. |
| M56187 | A-412997 | A-412997 is a selective Dopamine D4 agonist with Ki values of 12 and 7.9 nM for the rat and human receptors. |
| M56186 | SKF 81297 | SKF 81297 is a potent and selective dopamine D1 receptor agonist. |
| M56185 | GBR 12783 | GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. |
| M56184 | RMI-61140 | RMI-61140 is an orally active neuroleptics. |
| M56182 | Pericyazine | Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis. |
| M56181 | Sonepiprazole | Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively. |
| M56180 | Aplindore fumarate | Aplindore fumarate (DAB-452 fumarate) is a dopamine D2 receptor partial agonist. |
| M56179 | AJ-76 hydrochloride | AJ-76 hydrochloride ((+)-AJ 76 hydrochloride) is an antagonist of dopamine autoreceptor with pKi values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hD3, hD4, hD2S, hD2L and rD2 receptors, respectively. |
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