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Droperidol

Cat. No. M2655
Droperidol Structure
Synonym:

Dehydrobenzperidol

Size Price Availability Quantity
100mg USD 82  USD82 In stock
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Quality Control & Documentation
Biological Activity

Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system.

Chemical Information
Molecular Weight 379.43
Formula C22H22FN3O2
CAS Number 548-73-2
Form Solid
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] David McD Taylor, et al. Midazolam-Droperidol, Droperidol, or Olanzapine for Acute Agitation: A Randomized Clinical Trial

[2] Jack Perkins, et al. American Academy of Emergency Medicine Position Statement: Safety of Droperidol Use in the Emergency Department

[3] Michael C Thomas, et al. Droperidol for the treatment of acute migraine headaches

[4] L Budiharto, et al. Droperidol for the treatment of acutely agitated patients: still an option

[5] S Cure, et al. Droperidol for acute psychosis

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Keywords: Droperidol, Dehydrobenzperidol supplier, Dopamine Receptor, inhibitors, activators


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