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Phenothiazine

Cat. No. M2936
Phenothiazine Structure
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500mg USD 50  USD50 In stock
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Biological Activity

Phenothiazine is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain.

Chemical Information
Molecular Weight 199.27
Formula C12H9NS
CAS Number 92-84-2
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Maike J Ohlow, et al. Phenothiazine: the seven lives of pharmacology's first lead structure

[2] J N DELGADO, et al. PHENOTHIAZINE DERIVATIVES

[3] S COHEN. TP-21, a new phenothiazine

[4] R RAPPAPORT. Phenothiazine derivatives

[5] R Durst, et al. Phenothiazine-associated supraventricular tachycardia

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