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Pergolide mesylate

Cat. No. M2925
Pergolide mesylate Structure
Synonym:

LY127809

Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 80  USD80 In stock
50mg USD 220  USD220 In stock
100mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Pergolide mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.

Chemical Information
Molecular Weight 410.59
Formula C19H26N2S.CH4O3S
CAS Number 66104-23-2
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] D I Rendle, et al. Pharmacokinetics and pharmacodynamics of pergolide mesylate after oral administration in horses with pituitary pars intermedia dysfunction

[2] E Andrew Waller, et al. Pergolide-associated valvular heart disease

[3] Alexandr Jegorov, et al. Pergolide mesylate form II

[4] F R Levin, et al. Pergolide mesylate for cocaine abuse: a controlled preliminary trial

[5] G Pezzoli, et al. Pergolide mesylate in Parkinson's disease treatment

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