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Pimozide

Cat. No. M2945
Pimozide Structure
Synonym:

R6238

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50mg USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1.

Chemical Information
Molecular Weight 461.55
Formula C28H29F2N3O
CAS Number 2062-78-4
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jussara Maria Gonalves, et al. Inhibition of cancer stem cells promoted by Pimozide

[2] Robert Smyj, et al. Pimozide

[3] Tamara Pringsheim, et al. Pimozide for tics in Tourette's syndrome

[4] J Rathbone, et al. Pimozide for schizophrenia or related psychoses

[5] Willem A van Vloten. Pimozide: use in dermatology

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