Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Molecular Weight | 480.42 |
Formula | C21H24F3N3S.2HCl |
CAS Number | 440-17-5 |
Purity | >98% |
Solubility | DMSO 70 mg/mL |
Storage | at -20°C |
[1] Robert H Howland. Trifluoperazine: A Sprightly Old Drug
[3] Kai Koch, et al. Trifluoperazine versus placebo for schizophrenia
[4] L O Marques, et al. Trifluoperazine for schizophrenia
[5] R MACDONALD, et al. Trifluoperazine dihydrochloride (stelazine) in paranoid schizophrenia
Related Dopamine Receptor Products |
---|
A-381393
A-381393 IS AN EFFECTIVE, SELECTIVE, AND BLOOD-BRAIN BARRIER-PERMEABLE dopamine D4 receptor Antagonist, dopamine D for humans4.4,D4.2 AND D4.7 receptors Ki The values are 1.5, 1.9, and 1.6 nM, respectively, with selectivity being D1,D2,D3,D5 MORE THAN 2700 TIMES THE DOPAMINE RECEPTOR. A-381393 VS. 5-HT2A MODERATE SELECTIVITY, Ki The value is 370 nM. |
Pridopidine
Pridopidine is a dopamine (DA) stabilizer that acts as a low-affinity dopamine D2 receptor (D2R) antagonist. Pridopidine high affinity acts on sigma 1 receptor (S1R),Ki Values of 70 to 80 nM are approximately 100 times higher than their affinity for D2R. |
ML417
ML417 is a highly selective and brain penetrant D3 dopamine receptor (D3R) agonist, with EC50 of 38 nM. |
Cariprazine
Cariprazine is a D2 and D3 receptor partial agonist, with high selectivity towards the D3 receptor. |
PD-168077 maleate
PD-168077 maleate is a potent D4 dopamine receptor agonist (Ki = 8.7 nM), with > 400-fold and > 300-fold selectivity over D2 / D3 subtypes, respectively. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.