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Trifluoperazine dihydrochloride

Cat. No. M3087
Trifluoperazine dihydrochloride Structure

TFP; SKF5019

Size Price Availability Quantity
200mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.

Chemical Information
Molecular Weight 480.42
Formula C21H24F3N3S.2HCl
CAS Number 440-17-5
Solubility (25°C) DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Robert H Howland. Trifluoperazine: A Sprightly Old Drug

[2] Magdolna Tardy, et al. Trifluoperazine versus low-potency first-generation antipsychotic drugs for schizophrenia

[3] Kai Koch, et al. Trifluoperazine versus placebo for schizophrenia

[4] L O Marques, et al. Trifluoperazine for schizophrenia

[5] R MACDONALD, et al. Trifluoperazine dihydrochloride (stelazine) in paranoid schizophrenia

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Keywords: Trifluoperazine dihydrochloride, TFP; SKF5019 supplier, Dopamine Receptor, inhibitors, activators

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