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Brexpiprazole

Cat. No. M5467
Brexpiprazole Structure
Synonym:

OPC-34712, OPC 34712, OPC34712

Size Price Availability Quantity
10mg USD 90  USD100 In stock
25mg USD 162  USD180 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 433.57
Formula C25H27N3O2S
CAS Number 913611-97-9
Purity >98%
Solubility 24 mg/mL in DMSO
Storage at -20°C
References

A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia.
Kane JM, et al. Schizophr Res. 2015 May;164(1-3):127-35. PMID: 25682550.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Brexpiprazole, OPC-34712, OPC 34712, OPC34712 supplier, Dopamine Receptor, inhibitors

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