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Paliperidone

Cat. No. M5848
Paliperidone Structure
Synonym:

9-hydroxyrisperidone

Size Price Availability Quantity
50mg USD 58.5  USD65 In stock
100mg USD 90  USD100 In stock
500mg USD 270  USD300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 426.48
Formula C23H27FN4O3
CAS Number 144598-75-4
Purity >98%
Solubility 4 mg/mL warmed in DMSO
Storage at -20°C
References

Effectiveness of paliperidone palmitate vs haloperidol decanoate for maintenance treatment of schizophrenia: a randomized clinical trial.
McEvoy JP, et al. JAMA. 2014 May 21;311(19):1978-87. PMID: 24846035.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Paliperidone, 9-hydroxyrisperidone supplier, Dopamine Receptor, inhibitors

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