Free shipping on all orders over $ 500

BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1)

Cat. No. M8959

All AbMole products are for research use only, cannot be used for human consumption.

BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 112  USD112 In stock
1mg USD 48  USD48 In stock
5mg USD 108  USD108 In stock
10mg USD 176  USD176 In stock
25mg USD 340  USD340 In stock
50mg USD 498  USD498 In stock
100mg USD 688  USD688 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) is an inhibitor of PD-1/PD-L1 protein/protein interaction with an IC50 of 6 to 100 nM.

Product Citations
Chemical Information
Molecular Weight 475.58
Formula C29H33NO5
CAS Number 1675201-83-8
Solubility (25°C) DMSO: ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hualong Bai, et al. J Biomed Mater Res B Appl Biomater. Inhibition of programmed death-1 decreases neointimal hyperplasia after patch angioplasty

[2] Tsukahara T, et al. Expert Opin Biol Ther. The future of immunotherapy for sarcoma.

[3] Ngiow SF, et al. Oncoimmunology. Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600E melanoma.

[4] Bachireddy P, et al. Blood. Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion.

Related PD-1/PD-L1 Products
PD-1/PD-L1-IN-9

PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model.

NSC622608 

NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC50 value of 4.8 μM.

PD-L1-IN-1 

PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC50 of 115 nM.

SL-279252

SL-279252 (PD1-Fc-OX40L) is a hexameric, bi-functional fusion protein with an ECD of PD-1 (70 pM affinity to PD-L1) linked to the ECD of OX40L (324 pM affinity for OX40) through an Fc linker. SL-279252 exhibited linear PK at doses up to 3.0 mg/kg, and a greater than proportional increase in AUC was observed at 6.0 mg/kg suggesting potential receptor saturation. The preliminary half-life is approximately 23 hours.

Rosnilimab

Rosnilimab is a novel PD-1 checkpoint agonist antibody that reduces overactive T cell inflammation. Rosnilimab optimizes PD-1+ T cell inhibitory signaling by enabling tight immune synapse formation. Rosnilimab restores immune balance bringing T cell composition to a less activated state.

  Catalog
Abmole Inhibitor Catalog




Keywords: BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) supplier, PD-1/PD-L1, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.