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Fraxinellone was isolated from the root bark of the brassica family Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor that inhibits HIF-1α synthesis without affecting HIF-1α degradation. Fraxinellone has potential for cancer immunity by targeting PD-L1.
| Molecular Weight | 232.28 |
| Formula | C14H16O3 |
| CAS Number | 28808-62-0 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Christian Bailly, et al. Fraxinellone: From pesticidal control to cancer treatment
[4] Seung Min Jung, et al. Fraxinellone Attenuates Rheumatoid Inflammation in Mice
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