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Rosnilimab is a novel PD-1 checkpoint agonist antibody that reduces overactive T cell inflammation. It has two distinct mechanisms of action, depletion and agonism, prevalent both in inflamed tissue and the periphery, targeting PD-1+ T cells broadly impacting multiple drivers of disease pathogenesis.
Rosnilimab optimizes PD-1+ T cell inhibitory signaling by enabling tight immune synapse formation. Rosnilimab restores immune balance bringing T cell composition to a less activated state. Rosnilimab demonstrates potent depletion and agonism at clinically relevant concentrations.
| CAS Number | 2412764-40-8 |
| Storage | Store at ≤ -20°C. Aliquots should be stored at the same temperature after first use to avoid multiple freeze-thaws. |
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