4-Phenylbutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. 4-Phenylbutyric acid is also an inhibitor of endoplasmic reticulum (ER) stress. 4-Phenylbutyric acid (0-5 mM) inhibits ASFV infection in a dose-dependent manner. LPS decreases the level of p62, whereas 4-Phenylbutyric acid reverses this decrease upon LPS stimulation for 48 h. The percentage of cells with LPS-induced AVOs is increased at 48 h, whereas 4-Phenylbutyric acid significantly reduces this percentage. Specifically, the percentage of cells with AVOs decreases from 61.6% to 53.1% upon 4-Phenylbutyric acid treatment, supporting that 4-Phenylbutyric acid inhibits LPS-induced autophagy.
Small. 2023 Mar 12;e2208063.
2D MoS2 Nanosheets Induce Ferroptosis by Promoting NCOA4-Dependent Ferritinophagy and Inhibiting Ferroportin
4-Phenylbutyric acid (4-PBA) purchased from AbMole
New Phytol. 2023 Aug 22.
Orosomucoid proteins limit endoplasmic reticulum stress in plants
4-Phenylbutyric acid (4-PBA) purchased from AbMole
J Cell Physiol. 2023 Jan;238(1):151-164.
Polystyrene nanoplastics aggravates lipopolysaccharide-induced apoptosis in mouse kidney cells by regulating IRE1/XBP1 endoplasmic reticulum stress pathway via oxidative stress
4-Phenylbutyric acid (4-PBA) purchased from AbMole
Chemosphere. 2022 Nov;307(Pt 2):135962.
Fine particulate matter induces heart defects via AHR/ROS-mediated endoplasmic reticulum stress
4-Phenylbutyric acid (4-PBA) purchased from AbMole
Am J Pathol. 2021 Dec 5;192:468-483.
The role of inactivated NF-κB in the occurrence of premature ovarian failure
4-Phenylbutyric acid (4-PBA) purchased from AbMole
| Molecular Weight | 164.2 |
| Formula | C10H12O2 |
| CAS Number | 1821-12-1 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL Water 3 mg/mL at 40 ºC |
| Storage | 2-8°C, dry, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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