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4-Phenylbutyric acid (4-PBA)

Cat. No. M9638
4-Phenylbutyric acid (4-PBA) Structure
Synonym:

4-PBA; Benzenebutyric acid

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 38  USD38 In stock
500mg USD 44  USD44 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

4-Phenylbutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. 4-Phenylbutyric acid is also an inhibitor of endoplasmic reticulum (ER) stress. 4-Phenylbutyric acid (0-5 mM) inhibits ASFV infection in a dose-dependent manner. LPS decreases the level of p62, whereas 4-Phenylbutyric acid reverses this decrease upon LPS stimulation for 48 h. The percentage of cells with LPS-induced AVOs is increased at 48 h, whereas 4-Phenylbutyric acid significantly reduces this percentage. Specifically, the percentage of cells with AVOs decreases from 61.6% to 53.1% upon 4-Phenylbutyric acid treatment, supporting that 4-Phenylbutyric acid inhibits LPS-induced autophagy.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 164.2
Formula C10H12O2
CAS Number 1821-12-1
Purity >99%
Solubility DMSO ≥ 30 mg/mL
Water 3 mg/mL at 40 ºC
Storage 2-8°C, dry, protect from light, sealed
References

[1] Hyun-Jung Park, et al. Biochem Pharmacol. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts

[2] Goncalo Frouco, et al. Virus Res. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14

[3] Shengmin Yan, et al. Free Radic Biol Med. Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate

[4] Tsg-Hui Chang, et al. Clin Cancer Res. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung

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Keywords: 4-Phenylbutyric acid (4-PBA), 4-PBA; Benzenebutyric acid supplier, HDAC, inhibitors

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