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Abmole Inhibitor Catalog 2017

HDAC Histone deacetylases


Cat.No.  Name Information
M10534 Tucidinostat (Chidamide) HCl Tucidinostat (HBI-8000; Chidamide; CS-055) HCl is a benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10 with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.
M10079 ACY-775 ACY-775 is a potent and selective HDAC6 inhbiitor with IC50 of 7.5 nM.
M9890 SR-4370 SR-​4370 is a potent HDAC inhibitor.
M9638 4-Phenylbutyric acid (4-PBA) 4-Phenylbutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM.
M9633 Tasquinimod Tasquinimod is an oral antiangiogenic agent, it is also a S100A9 inhibitor.
M9480 BG45 BG45 is a potent and selective HDAC3 inhibitor with selectivity for HDAC3 (IC50 = 289 nM) over HDAC1, 2, 6.
M9217 Givinostat Givinostat is an HDAC inhibitor with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively.
M9206 Biphenyl-4-sulfonyl chloride Biphenyl-4-sulfonyl chloride is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
M9153 ACY-738 ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM.
M9143 HPOB HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs.
M9098 HDAC8-IN-1 HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines.
M9054 Valproic acid Valproic acid is an HDAC inhibitor with IC50 in the range of 0.5~2 mM.
M7857 ITSA-1 ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct aceytlation events (histone and tubulin).
M7374 TC-H 106 TC-H 106 is a class I histone deacetylase inhibitor, with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively.
M6178 Chidamide Chidamide is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.
M6176 TMP195 TMP195 is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays.
M6073 WT161 WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM.
M6070 EDO-S101 EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively.
M5259 Citarinostat Citarinostat (ACY-241) is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3, respectively. It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.
M5200 BRD73954 BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
M5199 Santacruzamate A Santacruzamate A is a picomolar level selective inhibitor of HDAC2 with an IC50 of 85.8 nM, a Class I HDAC, with relatively little inhibition of HDAC4 or HDAC6, both Class II HDACs.
M5152 Sodium Butyrate Sodium butyrate is the sodium salt of butyric acid, which has been reported to cause hyperacetylation of histones due to its role as a HDAC inhibitor with IC50 values of 0.3, 0.4, 0.3 mM for HDAC1, 2 and 7 respectively.
M4986 LMK-235 LMK235 is a HDAC inhibitor, previously shown to be a novel and specific inhibitor of human HDAC4 and 5, with IC50 values of 0.49 μM (A2780) and 0.32 μM (A2780 CisR).
M4868 Domatinostat (4SC-202) Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).
M4609 Raddeanin-A Raddeanin-A displays moderate inhibitory activity against histone deacetylases (HDACs) and has high antiangiogenic potency, antitumor activity.
M3988 Sulforaphane Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity.
M3979 Caffeic acid Caffeic acid is an endogenous phenolic phytochemical compound that exists in plants and many foods.
M3888 CAY10603 (BML-281) CAY10603 (BML-281) is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM.
M3643 TMP269 TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
M3405 AR-42 AR-42 is an HDAC inhibitor with IC50 of 30 nM.
M3395 M344 M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.
M3243 Pyroxamide Pyroxamide (NSC 696085) is a potent, affinity-purified HDAC1 inhibitor with ID50 of 100 nM.
M3095 Tubastatin A Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
M3022 Sodium Phenylbutyrate Sodium Phenylbutyrate is a transcriptional regulators that act by altering chromatin structure via the modulation of HDAC activity.
M3002 Scriptaid Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.
M2977 RGFP966 RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.
M2975 RG2833 RG2833 (RGFP109) is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
M2878 Nexturastat A Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM, >190-fold selectivity over other HDACs.
M2400 Apicidin Apicidin is a potent nonselective HDAC inhibitor with IC50 of 0.7 nM.
M2236 CI-994 CI-994 (N-acetyl dinaline, PD 123654) is a novel orally active HDAC inhibitor with IC50 of 0.57 μM for HDAC1.
M2123 Rocilinostat Rocilinostat (ACY-1215) is an HDAC6-selective inhibitor with IC50 of 5 nM.
M2119 JNJ-26481585 JNJ-26481585 (Quisinostat) is a novel second-generation class I HDAC inhibitor.
M2111 CUDC-907 CUDC-907 is a potent, orally-available small molecule dual PI3K and HDAC inhibitor.
M2101 PCI-34051 PCI-34051 is a potent histone deacetylase (HDAC) 8 inhibitor with IC50 of 0.01 μM.
M2095 Resminostat Resminostat is a potent inhibitor of HDACs 1, 3 and 6 [50% inhibitory concentration (IC50)=43-72 nmol/l] representing HDAC classes I and II.
M2014 MC1568 MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor with IC50 of 220 nM.
M2007 Romidepsin (FK228) Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.
M1993 Droxinostat Droxinostat is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively.
M1876 Valproic acid sodium salt Valproic acid (VPA) is a histone deacetylase inhibitor which is reported to enhance central GABAergic neurotransmission and inhibit Na+ channels.
M1813 PCI-24781 PCI-24781 is a novel and potent histone deacetylase (HDAC) inhibitor with IC50 value of 0.43 to 2.7 μM.

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