| Cat.No. | Name | Information |
|---|---|---|
| M1738 | Niltubacin | Niltubacin, as an inactive derivative of Tubacin, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6. |
| M1742 | Tubacin | Tubacin (Tubulin Acetylation Inducer) is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6 with IC50 of 0.004µM. |
| M1780 | Vorinostat | Vorinostat (SAHA, Zolinza, MK-0683) is a selective and potent histone deacetylase (HDAC) inhibitor with the IC50 value of 10 nM for HDAC-1. |
| M2007 | Romidepsin (FK228) | Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended |
| M1791 | Entinostat (MS-275) | Entinostat (MS-275) is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively. |
| M1748 | LBH589 (Panobinostat) | LBH589 (Panobinostat) is a novel broad-spectrum HDAC inhibitor for MOLT-4 and Reh cells with IC50 of 5 and 20 nM, respectively. |
| M4986 | LMK-235 | LMK235 is a HDAC inhibitor, previously shown to be a novel and specific inhibitor of human HDAC4 and 5, with IC50 values of 0.49 μM (A2780) and 0.32 μM (A2780 CisR). |
| M9638 | 4-Phenylbutyric acid (4-PBA) | 4-Phenylbutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. |
| M6176 | TMP195 | TMP195 is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays. |
| M5199 | Santacruzamate A | Santacruzamate A is a picomolar level selective inhibitor of HDAC2 with an IC50 of 85.8 nM, a Class I HDAC, with relatively little inhibition of HDAC4 or HDAC6, both Class II HDACs. |
| M41498 | CDK/HDAC-IN-3 | CDK/HDAC-IN-3 is an orally active HDACs/CDKs dual inhibitor. |
| M41497 | HDAC-IN-60 | HDAC-IN-60 is a potent histone deacetylase (HDAC) inhibitor. |
| M41496 | HDAC-IN-59 | HDAC-IN-59 is a potent histone deacetylase (HDAC) inhibitor. |
| M41493 | NT160 | NT160 is a highly potent class-IIa HDAC inhibitor with an IC50 value of 0.046 μM. |
| M41492 | HDAC6-IN-16 | HDAC6-IN-16 is a histone deacetylase 6 (HDAC6) inhibitor, based on Quinazolin-4(3H)-One. |
| M41491 | Bocodepsin | Bocodepsin (OKI-179) is an orally active and selective HDAC inhibitor, with antitumor activity. |
| M41490 | PB131 | PB131 is a selective and brain-permeable HDAC6 inhibitor with high binding affinity (IC50: 1.8 nM). |
| M41489 | JPS016 TFA | JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). |
| M41488 | Bocodepsin hydrochloride | Bocodepsin hydrochloride (OKI-179) is an orally active and selective HDAC inhibitor, with antitumor activity. |
| M41487 | 9-Hydroxyoctadecanoic acid | 9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ∼66.4% HDAC1 enzymatic activity at 5 μM. |
| M41486 | HDAC6-IN-18 | HDAC6-IN-18 is a first irreversible HDAC6 isoform selective inhibitor with potent anti-multiple myeloma activity. |
| M41485 | BChE/HDAC6-IN-1 | BChE/HDAC6-IN-1 is a potent and selective dual BChE/HDAC6 inhibitor with IC50 values of 4 and 8.9 nM, respectively. |
| M41484 | HDAC-IN-53 | HDAC-IN-53 is an orally active, and selective HDAC1-3 inhibitor with IC50 values of 47 nM, 125 nM, and 450 nM, respectively. |
| M41483 | cis-BG47 | cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. |
| M41482 | HDAC6-IN-17 | HDAC6-IN-17 is a potent HDAC6 inhibitor with IC50 values of 150 nM, 1400 nM, and 2300 nM for HDAC6, HDAC8, and HDAC4, respectively. |
| M41481 | HDAC-IN-57 | HDAC-IN-57 is an orally active inhibitor of histone deacetylases (HDAC), with IC50s of 2.07 nM, 4.71 nM, 2.4 nM and 107 nM for HDAC1, HDAC2, HDAC6, HDAC8, respectively. |
| M41480 | HDAC-IN-56 | HDAC-IN-56 ((S)-17b) is an orally active class I histone deacetylase (HDAC) inhibitor. |
| M40998 | Compound 25ap | Compound 25ap is a potent HDAC/JAK/BRD4 triple inhibitor designed based on the novel multi-targeted HDAC inhibitor Fedratinib, which promotes the hyperacetylation of histones and α-microtubulin, hypophosphorylation of STAT3, and down-regulation of LIFR, MCL-1, and c-Myc in MDA-MB-231 cells, and possesses antitumor activity. |
| M40605 | Snail/HDAC-IN-1 | Snail/HDAC-IN-1 is a potent Snail/HDAC dual-targeting inhibitor with strong inhibitory activity against HDAC1 with an IC50 value of 0.405 μM, and against Snail with a Kd of 0.18 μM. In addition, Snail/HDAC-IN-1 also increases histone H4 acetylation and decreases Snail protein expression in HCT-116 cells, thereby inducing apoptosis. In addition, Snail/HDAC-IN-1 also increased histone H4 acetylation in HCT-116 cells and decreased Snail protein expression, thereby inducing apoptosis. |
| M38926 | Pomiferin | Pomiferin (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 µM). |
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