Snail/HDAC-IN-1 is a potent Snail/HDAC dual-targeting inhibitor with strong inhibitory activity against HDAC1 with an IC50 value of 0.405 μM, and against Snail with a Kd of 0.18 μM. In addition, Snail/HDAC-IN-1 also increases histone H4 acetylation and decreases Snail protein expression in HCT-116 cells, thereby inducing apoptosis. In addition, Snail/HDAC-IN-1 also increased histone H4 acetylation in HCT-116 cells and decreased Snail protein expression, thereby inducing apoptosis.
| Molecular Weight | 488.54 |
| Formula | C24H21FN8OS |
| CAS Number | 2415281-52-4 |
| Form | Solid |
| Storage | 4°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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