About 30 results found for searched term "HDAC" (0.05 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3405 | AR-42 | HDAC |
| OSU-HDAC42; HDAC-42 | ||
| AR-42 is an HDAC inhibitor with IC50 of 30 nM. AR-42 induces growth inhibition, cell-cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. | ||
| M7394 | TCS HDAC6 20b | Others |
| TCS HDAC6 20b is a selective HDAC6 inhibitor. | ||
| M9098 | HDAC8-IN-1 | HDAC |
| ABM-7933; HDAC8 inhibitor 1 | ||
| HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. | ||
| M13675 | HDACs/mTOR Inhibitor 1 | HDAC |
| HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. | ||
| M20754 | GSK3117391 | HDAC |
| GSK3117391A, HDAC-IN-3 | ||
| GSK3117391 (GSK3117391A, HDAC-IN-3) is a potent histone deacetylase (HDAC) inhibitor. | ||
| M28041 | HDAC-IN-4 | HDAC |
| HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity. | ||
| M28474 | HDAC3-IN-T247 | HDAC |
| HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells. | ||
| M40605 | Snail/HDAC-IN-1 | HDAC |
| Snail/HDAC-IN-1 is a potent Snail/HDAC dual-targeting inhibitor with strong inhibitory activity against HDAC1 with an IC50 value of 0.405 μM, and against Snail with a Kd of 0.18 μM. In addition, Snail/HDAC-IN-1 also increases histone H4 acetylation and decreases Snail protein expression in HCT-116 cells, thereby inducing apoptosis. In addition, Snail/HDAC-IN-1 also increased histone H4 acetylation in HCT-116 cells and decreased Snail protein expression, thereby inducing apoptosis. | ||
| M40666 | A2AAR/HDAC-IN-1 | Adenosine Receptor |
| A2AAR/HDAC-IN-1 is an orally active A2AAR/HDAC inhibitor with anticancer activity with a Ki of 163.5 nM for A2AAR and an IC50 of 145.3 nM for HDAC1. | ||
| M41413 | HDAC10-IN-2 hydrochloride | Autophagy |
| HDAC10-IN-2 hydrochloride is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. | ||
| M41414 | HDAC-IN-62 | Autophagy |
| HDAC-IN-62 a HDAC inhibitor, with IC50s of 0.78, 1.0, 1.2? μM for HDAC6/8/11 respectively. | ||
| M41480 | HDAC-IN-56 | HDAC |
| HDAC-IN-56 ((S)-17b) is an orally active class I histone deacetylase (HDAC) inhibitor. | ||
| M41481 | HDAC-IN-57 | HDAC |
| HDAC-IN-57 is an orally active inhibitor of histone deacetylases (HDAC), with IC50s of 2.07 nM, 4.71 nM, 2.4 nM and 107 nM for HDAC1, HDAC2, HDAC6, HDAC8, respectively. | ||
| M41482 | HDAC6-IN-17 | HDAC |
| HDAC6-IN-17 is a potent HDAC6 inhibitor with IC50 values of 150 nM, 1400 nM, and 2300 nM for HDAC6, HDAC8, and HDAC4, respectively. | ||
| M41484 | HDAC-IN-53 | HDAC |
| HDAC-IN-53 is an orally active, and selective HDAC1-3 inhibitor with IC50 values of 47 nM, 125 nM, and 450 nM, respectively. | ||
| M41485 | BChE/HDAC6-IN-1 | HDAC |
| BChE/HDAC6-IN-1 is a potent and selective dual BChE/HDAC6 inhibitor with IC50 values of 4 and 8.9 nM, respectively. | ||
| M41486 | HDAC6-IN-18 | HDAC |
| HDAC6-IN-18 is a first irreversible HDAC6 isoform selective inhibitor with potent anti-multiple myeloma activity. | ||
| M41492 | HDAC6-IN-16 | HDAC |
| HDAC6-IN-16 is a histone deacetylase 6 (HDAC6) inhibitor, based on Quinazolin-4(3H)-One. | ||
| M41496 | HDAC-IN-59 | HDAC |
| HDAC-IN-59 is a potent histone deacetylase (HDAC) inhibitor. | ||
| M41497 | HDAC-IN-60 | HDAC |
| HDAC-IN-60 is a potent histone deacetylase (HDAC) inhibitor. | ||
| M41498 | CDK/HDAC-IN-3 | HDAC |
| CDK/HDAC-IN-3 is an orally active HDACs/CDKs dual inhibitor. | ||
| M41499 | HDAC-IN-61 | HDAC |
| HDAC-IN-61 is a potent and orally active HDAC inhibitor. | ||
| M41501 | HDAC6-IN-19 | HDAC |
| HDAC6-IN-19 is a HDAC6 inhibitor (IC50: 2.68 nM). | ||
| M41502 | HDAC8-IN-4 | HDAC |
| HDAC8-IN-4 is a selective inhibitor of HDAC8. | ||
| M41506 | HDAC-IN-58 | HDAC |
| HDAC-IN-58 is a HDAC inhibitor. | ||
| M41507 | HDAC-IN-64 | HDAC |
| HDAC-IN-64 is a HDAC inhibitor. | ||
| M41524 | Tubulin/HDAC-IN-2 | Microtubule |
| Tubulin/HDAC-IN-2 is a dual inhibitor of Tubulin and HDAC, with an IC50 of 0.403 μM, 0.591μM, 3.552μM, 0.459μM for HDAC1/2/3/6. | ||
| M41569 | HDAC/CD13-IN-1 | Others |
| HDAC/CD13-IN-1 is a HDAC/CD13 inhibitor (IC50: 0.34 μM for hCD13, 0.53 μM for porcine CD13, 0.03, 0.06, 0.02 μM for HDAC1/2/3). | ||
| M41607 | BChE/HDAC6-IN-2 | Tau Protein |
| BChE/HDAC6-IN-2 is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. | ||
| M41614 | Topo II/HDAC-IN-1 | Topoisomerase |
| Topo II/HDAC-IN-1 (7d) exhibits excellent dual inhibitory activities against Topo II and HDAC. | ||
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