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LBH589 (Panobinostat, NVP-LBH589) is a novel deacetylase inhibitor and has been shown to induce acetylation of histone H3 and H4, increase p21 levels, disrupt the chaperone function of hsp90, and induce cell-cycle G1 phase accumulation and apoptosis of K562 cells and acute leukemia MV4-11 cells. LBH589 (Panobinostat, NVP-LBH589) has also recently been found to significantly increase in vitro the survival of motor neuron (SMN) protein levels in cells of patients suffering from spinal muscular atrophy.
Biochem Pharmacol. 2024 Feb 17;116065.
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax
LBH589 (Panobinostat) purchased from AbMole
J Biol Chem. 2022 Sep;298(9):102314.
Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia
LBH589 (Panobinostat) purchased from AbMole
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
LBH589 (Panobinostat) purchased from AbMole
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Source | PLoS One (2015). Figure 2. LBH589 |
| Method | Apoptosis assay | |
| Cell Lines | SK-NEP-1 and G401 cells | |
| Concentrations | 50 nM | |
| Incubation Time | 24 h | |
| Results | The result showed that among cells treated with LBH589 50nM and 100nM for 24 hours, many more cells showed apoptotic feature compared with control group, for both SK-NEP-1 and G401 cells |
| Molecular Weight | 349.43 |
| Formula | C21H23N3O2 |
| CAS Number | 404950-80-7 |
| Solubility (25°C) | DMSO 59 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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