Free shipping on all orders over $ 500

Romidepsin (FK228)

Cat. No. M2007

All AbMole products are for research use only, cannot be used for human consumption.

Romidepsin (FK228) Structure
Synonym:

FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176

Size Price Availability Quantity
1mg USD 110  USD110 In stock
5mg USD 300  USD300 In stock
10mg USD 535  USD535 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively. Romidepsin inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. Romidepsin exhibits concentration-dependent cytotoxicity against a panel of mantle cell lymphoma (MCL) cell lines. FK228 (Romidepsin) treatment potently inhibits the neovascularization of chick embryo and that of adult mice in the Matrigel plug assay. FK228(Romidepsin) is currently in a Phase I study in treating patients with lymphoma, chronic lymphocytic leukemia, or solid tumors with liver dysfunction.*The compound is unstable in solutions, freshly prepared is recommended


Product Citations
Chemical Information
Molecular Weight 540.7
Formula C24H36N4O6S2
CAS Number 128517-07-7
Solubility (25°C) DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Coiffier B, et al. J Clin Oncol. Results from a pivotal, open-label, phase II study of romidepsin in relapsed or refractory peripheral T-cell lymphoma after prior systemic therapy.

[2] Piekarz RL, et al. Blood. Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma.

Related HDAC Products
T-518 

T-518 is an orally active, selective, and blood-brain barrier permeable HDAC6 inhibitor with an IC50 value of 36 nM for human HDAC6.

SE-7552 

SE-7552, a 2-(difluoromethyl)-1,3,4-oxadiazole (DFMO) derivative, is an orally active, highly selective, non-hydroxamate HDAC6 inhibitor with an IC50 of 33 nM.

BRD9757 

BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM.

MPT0B390 

MPT0B390 is an arylsulfonamide-based derivative with potent HDAC inhibitory ability.

HDAC-IN-40 

HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively.

  Catalog
Abmole Inhibitor Catalog




Keywords: Romidepsin (FK228), FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 supplier, HDAC, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.