All AbMole products are for research use only, cannot be used for human consumption.
Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
University of Otago. 2019.
Transcriptional effects of mood stabiliser drugs in a serotonergic cell line
Tubastatin A purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | normal human (i.e., H69) and rat (NRC) cholangiocyte cell lines |
| Preparation method | Proliferation assays Proliferation assays were conducted using the CellTiter 96 AQueous Non-Radioactive Cell Proliferation Assay (MTS; Promega) and/or counting cells using the Cellometer Auto4 (Nexcelom Bioscience) cell counter. |
| Concentrations | 0, 4 µ M |
| Incubation time | 3 days |
| Animal Experiment | |
|---|---|
| Animal models | orthotopic, syngeneic CCA model in rats |
| Formulation | saline |
| Dosages | 10 mg/kg daily for 7 days |
| Administration | intraperitoneally |
| Molecular Weight | 335.4 |
| Formula | C20H21N3O2 |
| CAS Number | 1252003-15-8 |
| Solubility (25°C) | DMSO 9 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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