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Tunicamycin

Cat. No. M4798
Tunicamycin Structure
Synonym:

NSC 177382, TN

Size Price Availability Quantity
5mg USD 270  USD270 In stock
10mg USD 420  USD420 In stock
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Quality Control & Documentation
Biological Activity

Tunicamycin inhibits GlcNAc phosphotransferase (GPT).Tunicamycin blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis.Tunicamycin can be used to induce autophagy.Tunicamycin induces apoptosis in association with caspase-3 activation, generation of reactive oxygen species (ROS), and downregulation of survivin expression.P38 MAPK (mitogen-activated protein kinase) and the generation of ROS signaling pathway play crucial roles in TN-induced apoptosis in U937 cells.TN modulates multiple components of the apoptotic response of human leukemia cells and raise the possibility of a novel therapeutic strategy for hematological malignancies.

Product Citations
Chemical Information
Molecular Weight 816.89
Formula C37H60N4O16
CAS Number 11089-65-9
Solubility (25°C) DMSO 30 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lim EJ, et al. Apoptosis. Tunicamycin promotes apoptosis in leukemia cells through ROS generation and downregulation of survivin expression.

[2] Lauer ME, et al. J Biol Chem. Primary murine airway smooth muscle cells exposed to poly(I,C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix.

[3] Duriez M, et al. J Biol Chem. The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated degradation pathway.

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Keywords: Tunicamycin, NSC 177382, TN supplier, Transferase, inhibitors, activators

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