Free shipping on all orders over $ 500

Tunicamycin

Cat. No. M4798

All AbMole products are for research use only, cannot be used for human consumption.

Tunicamycin Structure
Synonym:

NSC 177382, TN

Size Price Availability Quantity
1mg USD 90  USD90 In stock
5mg USD 270  USD270 In stock
10mg USD 420  USD420 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Tunicamycin inhibits GlcNAc phosphotransferase (GPT).Tunicamycin blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis.Tunicamycin can be used to induce autophagy.Tunicamycin induces apoptosis in association with caspase-3 activation, generation of reactive oxygen species (ROS), and downregulation of survivin expression.P38 MAPK (mitogen-activated protein kinase) and the generation of ROS signaling pathway play crucial roles in TN-induced apoptosis in U937 cells.TN modulates multiple components of the apoptotic response of human leukemia cells and raise the possibility of a novel therapeutic strategy for hematological malignancies.

Product Citations
Chemical Information
Molecular Weight 816.89
Formula C37H60N4O16
CAS Number 11089-65-9
Solubility (25°C) DMSO 30 mg/mL
Storage -20°C, protect from light, dry, sealed
References

[1] Lim EJ, et al. Apoptosis. Tunicamycin promotes apoptosis in leukemia cells through ROS generation and downregulation of survivin expression.

[2] Lauer ME, et al. J Biol Chem. Primary murine airway smooth muscle cells exposed to poly(I,C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix.

[3] Duriez M, et al. J Biol Chem. The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated degradation pathway.

Related Transferase Products
P053

P053 is a potent, non-competitive and selective ceramide synthase 1 (CerS1) inhibitor wirh an IC50 of 0.5 μM. P053 also acts as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle.

ABT-046 

ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of both 8 nM against human and mouse DGAT-1.

JTP-103237 

JTP-103237 is a MGAT2 inhibitor (IC50: 0.019 μM and 6.423 μM for hMGAT2 and hMGAT3 respectively).

PF-06424439 

PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM.

POP-3MB

POP-3MB is an ICMT inhibitor (IC50: 2.5 μM).

  Catalog
Abmole Inhibitor Catalog




Keywords: Tunicamycin, NSC 177382, TN supplier, Transferase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.