| Cat.No. | Name | Information |
|---|---|---|
| M4798 | Tunicamycin | Tunicamycin is a mixture of nucleoside antibiotics that inhibits N-glycosylation and blocks GlcNAc phosphotransferase (GPT). |
| M39049 | Enniatin B1 | Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes. Enniatin B1 can cross the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation. |
| M27868 | Fumonisin B1 | Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin. |
| M25436 | EGR240 | ERG240 is a selective inhibitor of branched-chain aminotransferase 1 (BCAT1) with an IC50 of 0.1-1nM. ERG240 leads to decreased oxygen consumption and glycolysis through the down regulation of IRG1 expression, which leads to decrease itaconate production in human macrophages. |
| M21597 | Beauvericin | Beauvericin is a fusarium toxin. It has a wide range of antifungal, antibacterial, protozoal and insecticidal activities, exhibits ionic properties and inhibits acyl-coenzyme: cholesterol acyltransferase activity; Apoptosis was induced by increasing intracellular calcium levels. |
| M20843 | NNMTi | NNMTi (Compound 1k, NNMT inhibitor) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.2 μM. |
| M16083 | Seneciphylline | Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities. |
| M14767 | SHIN1 | SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. |
| M14294 | OSMI-4 | OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells. |
| M11323 | 10,12-Tricosadiynoic acid | Tricosadiynoic acid, 10,12-Tricosadiynoic acid, is A highly specific, selective, high-affinity acyl-coa oxidase-1 (ACOX1) inhibitor with oral activity. Tricosadiynoic acid can improve mitochondrial lipid and ROS metabolism and can be used to study metabolic diseases caused by high fat diet or obesity. |
| M10176 | 3-Methoxybenzamide | 3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT). |
| M10100 | Opicapone | Opicapone, also known as BIA 9-1067, is a novel potent and selective catechol-O-methyltransferase inhibitor (COMT inhibitor). |
| M9349 | Adenosine Dialdehyde | Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM. |
| M9234 | Hecogenin | Hecogenin is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM. |
| M8728 | ESI-05 | Esi-05 (NSC 116966) is a camp-specific direct activated exchange protein 2 (EPAC2) antagonist with an IC50 value of 0.4 µM that inhibits camp-induced EPAC2 activation and EAPC2-mediated Rap1 activation. |
| M8587 | OSMI-1 | OSMI-1 is a cell permeable inhibitor of OGT (O-GlcNAc transferase) with an IC50 value of 2.7 μM. |
| M8202 | Sandoz 58-035 | Sandoz 58-035 is a cholesterol acyltransferase (ACAT) inhibitor. Sandoz 58-035 inhibits the accumulation of cholesteryl esters and inhibits the esterification of cholesterol by 95% in arterial smooth muscle cells in culture. Sandoz 58-035 was used to induce simultaneous activation of unfolded protein response (UPR) and pattern recognition receptors (PRRs) in mouse peritoneal macrophages. |
| M3078 | Tolcapone | Tolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM. |
| M2307 | Lonafarnib | Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. |
| M2287 | APO866 | APO866 is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase; NAMPT) with an IC50 of 0.09 nM. |
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